PMID: 9191015May 1, 1997Paper

In vitro antiviral activities of myristic acid analogs against human immunodeficiency and hepatitis B viruses

Antiviral Research
K ParangF Csizmadia

Abstract

A group of myristic acid analogs, designed as alternative substrates for N-myristoyltransferase (NMT), were evaluated against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and duck hepatitis B virus (DHBV) in vitro. Antiviral potency was increased when S or O was substituted for -CH2- in myristic acid and selectivity was affected by the presence and position of the heteroatoms and phenyl groups. A correlation was established among anti-HIV activity, Log P and Log D7.4 and between anti-HIV activity and carbonyl-heteroatom interatomic distances in the myristoyl analogs. 12-Thioethyldodecanoic acid 6 was moderately active (EC50 = 9.37 microM) against HIV-infected T4-lymphocytes (CEM-SS cell line), and it exhibited in vitro activity (EC50 = 17.8 microM) against HBV-producing 2.2.15 cell cultures derived from a human hepatoblastoma cell line (Hep G2). 12-Methoxydodecanoic acid 1 exhibited in vitro activity (EC50 = 20-30 microM) against hepatitis B in the HBV DNA-transfected 2.2.15 cell line. At a concentration of 10 microg/ml, none of the fatty acids significantly inhibited the replication of DHBV in infected hepatocytes.

References

Mar 1, 1991·Antiviral Research·B E Korba, G Milman
Oct 1, 1990·Trends in Biochemical Sciences·R A McIlhinney
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M L BryantJ I Gordon
Jan 1, 1988·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·M Eisenhut, J Liefhold
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G AcsH Popper
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M A SellsG Acs
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R O HeuckerothJ I Gordon
Nov 1, 1996·Archiv der Pharmazie·K ParangF Csizmadia
Feb 27, 2001·Acta Crystallographica. Section D, Biological Crystallography·K FüttererG Waksman

❮ Previous
Next ❯

Citations

Apr 11, 2000·Lipids·J Raulin
May 8, 2013·Chemistry and Physics of Lipids·Elsie A OrellanoNéstor M Carballeira
Mar 31, 2004·Trends in Microbiology·Sebastian Maurer-Stroh, Frank Eisenhaber
Aug 10, 2002·Progress in Lipid Research·N M Carballeira
Dec 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J HuL Wang
Jun 6, 2000·Advanced Drug Delivery Reviews·L I Wiebe, E E Knaus
Dec 28, 1999·Microbes and Infection·S M CordoE B Damonte
Apr 27, 2012·Journal of Medicinal Chemistry·Hitesh K AgarwalKeykavous Parang
Sep 29, 2004·Journal of Virology·Mar PerezJuan Carlos de la Torre
Nov 7, 2006·Virology Journal·Thomas StreckerWolfgang Garten
Mar 28, 2012·Journal of Oleo Science·Thamil Vaani Komarasamy, Shamala Devi Sekaran
Sep 9, 2015·Lipids·Lizabeth Giménez MoreiraNéstor M Carballeira
Aug 2, 2002·Expert Opinion on Investigational Drugs·Nafsika H Georgopapadakou
Aug 25, 2012·Molecular Pharmaceutics·Hitesh K AgarwalKeykavous Parang
Aug 12, 2014·Journal of Medical Virology·Steven TracyNora Chapman
Mar 9, 2011·Bioorganic & Medicinal Chemistry Letters·Hitesh K AgarwalKeykavous Parang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Plant Foods for Human Nutrition
Siwapong TansuwanwongUsanee Vinitketkumnuen
Water Science and Technology : a Journal of the International Association on Water Pollution Research
P KemacheevakulY Shimizu
© 2021 Meta ULC. All rights reserved