In vitro antiviral activity of twenty-seven medicinal plant extracts from Southwest Nigeria against three serotypes of echoviruses

Virology Journal
Omonike O OgboleAdekunle J Adeniji

Abstract

Echoviruses, a serotype of enteroviruses, infect millions of people globally and there is no specific drug treatment or vaccine available for its management. The screening of medicinal plants used locally for the treatment of infectious diseases, can provide a reliable option in the discovery of potent therapeutic compounds. This study was carried out to investigate the antiviral activities of 27 medicinal plant extracts, belonging to 26 different plant species, selected from Nigerian ethnobotany, against echovirus 7, 13 and 19 serotypes (E7, E13 and E19, respectively). The plants were macerated in methanol and the cytotoxicities of the crude extracts were evaluated on the rhabdomyosarcoma cell line using the MTT assay. The antiviral activity of the plant extracts and fractions against echoviruses (E7, E13, and E19) was determined using the neutralisation assay, an assay that measures the inhibition of cytopathic effect on cell culture. The crude extract of Macaranga barteri leaves had the highest cytotoxicity with CC50 value of 0.27 μg/mL. This was followed by Crinum jagus (9.88 μg/mL) and Terminalia ivorensis (12.14 μg/mL). The antiviral screening showed that ten out of the 27 crude plant extracts tested were active on E7 and...Continue Reading

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Citations

Jul 26, 2019·Natural Product Research·Peter A SegunAdekunle J Adeniji
Oct 11, 2020·Phytotherapy Research : PTR·Bikash AdhikariNiranjan Parajuli
Oct 9, 2020·TheScientificWorldJournal·Harriet U UgbokoConrad A Omonhinmin
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco MasiAntonio Evidente
Nov 10, 2020·Indian Journal of Clinical Biochemistry : IJCB·Jaykaran CharanPraveen Sharma
Nov 13, 2020·Frontiers in Plant Science·Anamika PandeySait Gezgin
Feb 2, 2021·Biocatalysis and Agricultural Biotechnology·Tariq KhanAkhtar Nadhman
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arumugam Vijaya AnandKuldeep Dhama
Jun 3, 2021·Viruses·Maria Musarra-PizzoMaria Teresa Sciortino
Jul 6, 2021·Metabolism Open·Akeberegn Gorems AyeleZemene Demelash Kifle
Jul 3, 2021·International Journal of Environmental Research and Public Health·Kunle Okaiyeto, Oluwafemi O Oguntibeju
Jun 22, 2021·Antimicrobial Agents and Chemotherapy·Seydou KaIsabel Desgagné-Penix
Dec 26, 2021·Letters in Applied Microbiology·Lucy OwenMaitreyi Shivkumar

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