Abstract
Echoviruses, a serotype of enteroviruses, infect millions of people globally and there is no specific drug treatment or vaccine available for its management. The screening of medicinal plants used locally for the treatment of infectious diseases, can provide a reliable option in the discovery of potent therapeutic compounds. This study was carried out to investigate the antiviral activities of 27 medicinal plant extracts, belonging to 26 different plant species, selected from Nigerian ethnobotany, against echovirus 7, 13 and 19 serotypes (E7, E13 and E19, respectively). The plants were macerated in methanol and the cytotoxicities of the crude extracts were evaluated on the rhabdomyosarcoma cell line using the MTT assay. The antiviral activity of the plant extracts and fractions against echoviruses (E7, E13, and E19) was determined using the neutralisation assay, an assay that measures the inhibition of cytopathic effect on cell culture. The crude extract of Macaranga barteri leaves had the highest cytotoxicity with CC50 value of 0.27 μg/mL. This was followed by Crinum jagus (9.88 μg/mL) and Terminalia ivorensis (12.14 μg/mL). The antiviral screening showed that ten out of the 27 crude plant extracts tested were active on E7 and...Continue Reading
References
Apr 1, 1990·Journal of Ethnopharmacology·T A John, A O Onabanjo
Dec 16, 1983·Journal of Immunological Methods·T Mosmann
Mar 1, 1997·Journal of Ethnopharmacology·A K RawatU Shome
Feb 17, 2001·Phytotherapy Research : PTR·P WatchoN Koueta
Jan 22, 2002·Journal of Ethnopharmacology·P CosA J Vlietinck
Feb 28, 2002·Fitoterapia·Adewole L Okunade
May 3, 2003·Fitoterapia·A A AbenaJ M Ouamba
Aug 13, 2003·Journal of Applied Microbiology·S A A Jassim, M A Naji
Jan 18, 2005·Journal of Ethnopharmacology·S AmosK Gamaniel
Jul 12, 2007·The West Indian Medical Journal·L A D WilliamsE N Barton
Jun 15, 2010·Phytochemistry·Dulcie A MulhollandJean-Marc Nuzillard
Jul 19, 2011·Chemistry & Biodiversity·Beaudelaire Kemvoufo PonouLéon Azefack Tapondjou
Dec 31, 2011·Environmental Health and Preventive Medicine·Mohammad Iqbal, Charles Gnanaraj
Apr 3, 2012·Journal of Virological Methods·Ying-Ju LinCheng-Wen Lin
Oct 11, 2012·Ayu·Chandrakant KatiyarShefali Katiyar
Oct 12, 2012·Pharmacognosy Reviews·Hafsa AhmadRajiv Gupta
Oct 15, 2013·The Journal of Infection·Mark J Abzug
Jan 15, 2014·Asian Pacific Journal of Tropical Medicine·Osayemwenre ErharuyiPeter Langer
Sep 2, 2014·Pathogens and Global Health·Shikha JainGirish Chandra Bhatt
Nov 29, 2014·Pharmaceutical Biology·Ogbole Omonike OluyemisiMuhammad Iqbal Choudhary
Mar 17, 2015·Journal of Ethnopharmacology·Idris Ajayi OyemitanMoses Atanda Akanmu
Apr 12, 2015·Fitoterapia·Da-Song YangWei-Lie Xiao
May 27, 2015·Journal of Integrative Medicine·Oluwatosin AdaramoyeAnja Rabien
Aug 13, 2015·Viruses·Lonneke van der LindenFrank J M van Kuppeveld
Sep 4, 2015·MMWR. Morbidity and Mortality Weekly Report·Glen R AbediSusan I Gerber
Jul 29, 2016·Scientific Reports·Madeleine ErnstNina Rønsted
Jan 8, 2015·Toxicology Reports·Saheed SabiuAbdulazeez Balogun
Nov 21, 2017·Journal of Medicinal Plant Research·Joshua M HenkinDjaja D Soejarto
Nov 24, 2017·BMC Complementary and Alternative Medicine·Omonike O OgboleAdekunle J Adeniji
Citations
Jul 26, 2019·Natural Product Research·Peter A SegunAdekunle J Adeniji
Jul 21, 2020·Journal of Biomolecular Structure & Dynamics·Toluwase Hezekiah FatokiJesupemi Mercy Enibukun
Sep 11, 2020·Nanomaterials·Sundus RiazSyed Mohsin Ali
Dec 4, 2019·Virology Journal·Vladimir BerezinAzliyati Azizan
Oct 11, 2020·Phytotherapy Research : PTR·Bikash AdhikariNiranjan Parajuli
Oct 9, 2020·TheScientificWorldJournal·Harriet U UgbokoConrad A Omonhinmin
Oct 23, 2020·Journal of Biomolecular Structure & Dynamics·Gideon A GyebiOlalekan B Ogunro
Dec 30, 2020·Antiviral Chemistry & Chemotherapy·Oludare M OgunyemiIbrahim M Ibrahim
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco MasiAntonio Evidente
Nov 10, 2020·Indian Journal of Clinical Biochemistry : IJCB·Jaykaran CharanPraveen Sharma
Nov 13, 2020·Frontiers in Plant Science·Anamika PandeySait Gezgin
Feb 2, 2021·Biocatalysis and Agricultural Biotechnology·Tariq KhanAkhtar Nadhman
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arumugam Vijaya AnandKuldeep Dhama
May 14, 2021·Frontiers in Pharmacology·Alfred Francis AttahChinedum Peace Babalola
Jun 3, 2021·Viruses·Maria Musarra-PizzoMaria Teresa Sciortino
Jul 1, 2021·Virusdisease·Thi Bich Ngoc TrinhThao Kim Nu Nguyen
Jul 6, 2021·Metabolism Open·Akeberegn Gorems AyeleZemene Demelash Kifle
Jul 3, 2021·International Journal of Environmental Research and Public Health·Kunle Okaiyeto, Oluwafemi O Oguntibeju
Aug 6, 2021·Virology Journal·Omonike O OgboleAdekunle J Adeniji
Jun 22, 2021·Antimicrobial Agents and Chemotherapy·Seydou KaIsabel Desgagné-Penix
Nov 10, 2021·Journal, Genetic Engineering & Biotechnology·Tolulope Peter SaliuOlusola Olalekan Elekofehinti
Dec 26, 2021·Letters in Applied Microbiology·Lucy OwenMaitreyi Shivkumar