PMID: 591127Dec 15, 1977

In vitro assessment of immunocompetence in patients with malignant melanoma

International Journal of Cancer. Journal International Du Cancer
S H GolubD L Morton

Abstract

Ninety-four patients with malignant melanoma and 96 healthy controls were tested for lymphocyte proliferative capacity in a microblastogenesis assay. Each lymphocyte sample was assayed for incorporation of (3H)thymidine after stimulation with PHA, PWM, Con A (two doses), PPD, and allogeneic lymphocytes (MLC). MLC was the only assay that revealed a substantial and significant difference between the melanoma patients and controls. Almost all assays showed lower values in patients with more advanced disease. However, it was not possible to accurately predict clinical outcome from data obtained from in vitro immunocompetence tests. These results indicate the relatively limited clinical usefulness of assays of lymphocyte proliferative capacity in melanoma patients.

References

Jan 1, 1977·International Journal of Cancer. Journal International Du Cancer·S H GolubD L Morton
Sep 15, 1976·International Journal of Cancer. Journal International Du Cancer·A J CochranA M Jackson
Oct 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C ButterworthJ R Hobbs
Oct 1, 1974·Annals of Surgery·D L MortonF C Sparks
Sep 15, 1971·International Journal of Cancer. Journal International Du Cancer·G FossatiU Veronesi

Related Concepts

Cellular Immune Response
Lymphocyte Activation
Lymphoid Cells
Melanoma
Phytomitogens
Hypersensitivity Skin Testing

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