PMID: 9554175Apr 29, 1998Paper

In vitro assessment of the antimicrobial activity of a local sustained release device containing amine fluoride for the treatment of oral infectious diseases

Diagnostic Microbiology and Infectious Disease
S ShaniD Steinberg

Abstract

Dental caries and periodontal diseases are chronic infectious diseases caused by oral bacteria. Local sustained release delivery systems extend the time in which the drug is present in the oral cavity, thus enhancing its therapeutic potential while reducing its side effects. Amine-fluorides (AmF) are known anticaries agents and have recently been found to have an antibacterial effect against periodontal pathogens and caries-associated bacteria. The purpose of this in vitro study was to assess the antimicrobial activity of a local sustained release device (LSRD) containing AmF on Streptococcus sobrinus 6715. LSRD was prepared from an ethylcellulose matrix containing AmF. Release kinetics of AmF from the LSRD was measured simultaneously with its antimicrobial activity. The organic amine and the fluoride were released in different kinetics profiles: The fluoride was released faster than the organic amine. The antimicrobial activity of AmF was measured on planktonic bacteria in solution and on bacteria as part of experimental dental plaque. During a 10-day period, the concentration of the released AmF was above its MIC and no bacterial growth was observed. Bacterial counts in the dental plaque were reduced by 1 to 2 log units. Henc...Continue Reading

References

Jul 1, 1990·Journal of Periodontal Research·M TonettiJ M Goodson
Aug 1, 1990·Journal of Clinical Periodontology·G S BansalM Wilson
Jan 1, 1989·The Journal of Antimicrobial Chemotherapy·S BullockM Wilson
Nov 1, 1973·Archives of Oral Biology·O G GoldJ Van Houte
Aug 1, 1996·The Journal of Applied Bacteriology·S L KinnimentP D Marsh
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·W F Liljemark, C Bloomquist
Nov 1, 1996·Diagnostic Microbiology and Infectious Disease·D Steinberg, M Rothman
Jan 1, 1988·Journal of Dental Research·K M Schilling, W H Bowen

❮ Previous
Next ❯

Citations

Apr 20, 2000·Journal of Clinical Pharmacy and Therapeutics·S P VyasV Mishra
Feb 2, 2013·International Journal of Pharmaceutical Investigation·Mohammad TariqJasjeet K Sahni
Aug 16, 2011·Journal of Mathematical Psychology·F Gregory Ashby, Sebastien Helie
Aug 3, 2010·Phytotherapy Research : PTR·Michał TomczykMałgorzata Pleszczyńska
Jul 28, 2016·Expert Opinion on Drug Delivery·Doron Steinberg, Michael Friedman
Mar 2, 2017·European Journal of Oral Sciences·Elena M VaroniLia Rimondini
Dec 20, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Doron SteinbergMichael Friedman
Mar 15, 2006·The Journal of Antimicrobial Chemotherapy·Osnat FeuersteinDoron Steinberg
Nov 29, 2007·Caries Research·H C van der MeiH J Busscher
Apr 13, 2015·Medical & Biological Engineering & Computing·Seppo P Ahlfors, Christopher Wreh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.