In vitro bactericidal activities of daptomycin against Staphylococcus aureus and Enterococcus faecalis are not mediated by inhibition of lipoteichoic acid biosynthesis

Antimicrobial Agents and Chemotherapy
Valerie LaganasJared Silverman

Abstract

Previous studies have suggested that lipoteichoic acid biosynthesis inhibition is the mechanism of action of daptomycin. In this investigation, daptomycin inhibited all macromolecular synthesis in Staphylococcus aureus, Enterococcus faecalis, and Enterococcus hirae without kinetic or dose specificity for lipoteichoic acid. Daptomycin remained bactericidal in the absence of ongoing lipoteichoic acid synthesis. Inhibition of lipoteichoic acid synthesis is apparently not the mechanism of action of daptomycin in these pathogens.

References

Nov 11, 1991·Antimicrobial Agents and Chemotherapy·W E AlbornD A Preston
Dec 11, 1991·Antimicrobial Agents and Chemotherapy·N E AllenJ N Hobbs
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·P CanepariG Satta
Jan 1, 1988·Advances in Microbial Physiology·W Fischer
May 1, 1994·Medical Microbiology and Immunology·W Fischer
Nov 18, 2000·Antimicrobial Agents and Chemotherapy·D R SnydmanJ M Boyce
May 17, 2001·Antimicrobial Agents and Chemotherapy·J A SilvermanT Li
May 17, 2001·Antimicrobial Agents and Chemotherapy·A L BarryS D Brown
Aug 2, 2001·The Journal of Antimicrobial Chemotherapy·A King, I Phillips
Feb 28, 2002·The Journal of Antimicrobial Chemotherapy·Peter C FuchsS D Brown
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Jared SilvermanHoward M Shapiro
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

Citations

Oct 31, 2007·European Biophysics Journal : EBJ·Steven W HoSuzana K Straus
Sep 30, 2005·Journal of Industrial Microbiology & Biotechnology·Richard H BaltzStephen K Wrigley
Jan 26, 2008·Molecular Pharmaceutics·Elizabeth A FelnagleMichael G Thomas
Nov 29, 2005·Natural Product Reports·Richard H BaltzStephen K Wrigley
Mar 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher F Carpenter, Henry F Chambers
Oct 10, 2008·The Journal of Antimicrobial Chemotherapy·P M Hawkey
May 9, 2009·The Journal of Antimicrobial Chemotherapy·Vidya MaveRodrigo Hasbun
Oct 10, 2007·Antimicrobial Agents and Chemotherapy·Carmela T M MascioJared Silverman
Jan 24, 2009·Antimicrobial Agents and Chemotherapy·Anna-Barbara HachmannJohn D Helmann
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Jared SilvermanHoward M Shapiro
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Klaudia KosowskaPeter C Appelbaum
Jul 20, 2004·Drugs·Murugan Raghavan, Peter K Linden
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Angelika Gründling, Olaf Schneewind
Mar 24, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·David R P Guay
Oct 10, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan González Del CastilloFrancisco Javier Martín-Sánchez
May 20, 2006·Scandinavian Journal of Infectious Diseases·N KvirikadzeK Singh
Mar 6, 2013·Expert Review of Anti-infective Therapy·Isabella KanzlerAndres Beiras-Fernandez
Aug 28, 2004·Expert Opinion on Investigational Drugs·Barry I Eisenstein
Jun 7, 2005·Expert Opinion on Emerging Drugs·Florian M E WagenlehnerKurt G Naber
May 11, 2012·Enfermedades infecciosas y microbiología clínica·Francisco Javier Candel González
Apr 7, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·John A Segreti
May 27, 2014·Biochimica Et Biophysica Acta·TianHua ZhangMichael Palmer
May 13, 2006·Molecular Microbiology·Amit P Bhavsar, Eric D Brown
Nov 9, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yi-Lin WenLong-Sen Chang
Jan 11, 2005·Clinical Therapeutics·LilyAnn Jeu, Horatio B Fung
May 18, 2011·Toxicon : Official Journal of the International Society on Toxinology·Li-Wen ChenLong-Sen Chang
Nov 16, 2004·Diagnostic Microbiology and Infectious Disease·H S SaderRonald N Jones
Sep 12, 2006·International Journal of Antimicrobial Agents·Glenn W KaatzSusan M Seo
Jan 18, 2006·European Urology·Florian M E Wagenlehner, Kurt G Naber
Mar 12, 2013·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroki KinouchiHiroshi Kamimori
Apr 23, 2015·International Journal of Antimicrobial Agents·Venkateswarlu YarlagaddaJayanta Haldar
Mar 11, 2015·Archives of Biochemistry and Biophysics·Chia-Yu TsaiLong-Sen Chang
Dec 3, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E Bouza
Sep 28, 2016·ACS Infectious Diseases·Jin ZhangSuzana K Straus
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Anna MüllerLeendert W Hamoen
Jun 3, 2004·The Journal of Biological Chemistry·Palaniappan KulanthaivelSheng-Bin Peng
Jun 18, 2014·Antimicrobial Agents and Chemotherapy·Bruk MensaWilliam F DeGrado
Mar 13, 2014·The Journal of Biological Chemistry·TianHua ZhangEvan Mintzer
Feb 22, 2005·The Journal of Antimicrobial Chemotherapy·Jennifer M StreitRonald N Jones
Jan 27, 2004·Pharmacotherapy·Kerry L Tedesco, Michael J Rybak
Oct 15, 2014·Current Opinion in Infectious Diseases·Pranita D Tamma, Alice J Hsu
Jul 7, 2017·Proteome Science·Michael P GotsbacherPeter Karuso
Mar 23, 2021·Accounts of Chemical Research·Cameron C HannaMargaret A Brimble

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.