PMID: 11909842Mar 23, 2002Paper

In vitro bactericidal activity of ABT-773 and amoxicillin against erythromycin-susceptible and -resistant strains of Streptococcus pyogenes

The Journal of Antimicrobial Chemotherapy
Susan L PendlandJennifer L Prause

Abstract

The bactericidal activity of ABT-773 was compared with amoxicillin against 10 clinical isolates of S. pyogenes (six erythromycin susceptible and four erythromycin resistant). The MIC ranges (mg/L) were 0.004-0.25 of ABT-773 and 0.015-0.12 of amoxicillin. At 24 h, ABT-773 concentrations of 2 x MIC and 8 x MIC were bactericidal against three and six organisms, respectively. In comparison, amoxicillin was bactericidal against all 10 organisms at both test concentrations.

References

Oct 6, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A L BisnoR H Schwartz
Apr 23, 1999·Diagnostic Microbiology and Infectious Disease·C BetriuJ J Picazo
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·I OdenholtO Cars
Jun 16, 2001·Antimicrobial Agents and Chemotherapy·A M NiliusR K Flamm

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Citations

Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Bryskier
Feb 26, 2010·Pharmacotherapy·Sally RafieCharles L James

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