In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood

The Journal of Clinical Investigation
P G QuieR A Good

Abstract

Diminished bactericidal capacity was found to be characteristic of polymorphonuclear leukocytes (PMN) from five children with the clinical syndrome of granulomatous disease of childhood. The PMN from these children demonstrated nearly normal phagocytic capacity, and the majority of viable bacteria, after 2 hours of incubation in the phagocytosis system, were found associated with leukocytes. The morphology of the unstimulated polymorphonuclear leukocytes from patients with chronic granulomatous disease was similar to those from normal persons of similar ages by light and electron microscopy. In addition, the total lysozyme and phagocytin activity of leukocyte extracts from these patients was similar to those from equal numbers of leukocytes from controls.A striking difference in the cytoplasmic response after phagocytosis characterized the PMN of the patients with granulomatous disease. Whereas degranulation, vacuole formation, and rapid bacterial digestion were the rule in the PMN from controls, little degranulation and persistence of intact bacteria in the cytoplasm characterized disease. The deficiency of bactericidal capacity and the minimal degranulation after active phagocytosis by the PMN of these children with an inheri...Continue Reading

References

Mar 24, 1955·Annals of the New York Academy of Sciences·J W REBUCK, J H CROWLEY
Dec 1, 1960·The Journal of Experimental Medicine·Z A COHN, J G HIRSCH
Mar 1, 1960·The Journal of Experimental Medicine·J G HIRSCH
Sep 1, 1959·The Journal of Experimental Medicine·Z A COHN, S I MORSE

❮ Previous
Next ❯

Citations

Dec 1, 1993·Journal of Cellular Physiology·M J Zhou, H R Petty
Jan 1, 1980·Human Genetics·G WolffA Jobke
Jan 1, 1983·Human Genetics·W H Hitzig, R A Seger
Jan 1, 1991·Acta Neuropathologica·M G HadfieldW M Kramer
Oct 1, 1986·European Journal of Pediatrics·C P SpeerM Gahr
Sep 1, 1986·European Journal of Pediatrics·N UenoS Matsumoto
Jun 1, 1987·Inflammation·T A GaitherM M Frank
Jan 1, 1984·Pediatric Radiology·D D StricofM A Amendola
Jun 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H van BronswijkJ Verhoef
Apr 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A PascualE J Perea
May 1, 1989·Indian Journal of Pediatrics·K C NayakK K Kumar
Aug 5, 2004·Histochemistry and Cell Biology·William M Nauseef
May 1, 1974·American Journal of Surgery·T F O'DonnellL Stolberg
Jul 6, 1981·Biochimica Et Biophysica Acta·V CastranovaK Vandyke
Jan 1, 1975·Journal of Immunological Methods·R GangulyR H Waldman
May 27, 1983·Journal of Immunological Methods·S H BoghossianA W Segal
Nov 30, 1989·Journal of Immunological Methods·P Stinavage, J K Spitznagel
May 12, 1989·Journal of Immunological Methods·R Bellinati-PiresM M Carneiro-Sampaio
Oct 1, 1976·Journal of the Neurological Sciences·A Czlonkowska, B Milewski
Jan 1, 1978·Journal of the Neurological Sciences·A R SeayH R Hill
Mar 1, 1986·Journal of the Neurological Sciences·U KaragolF L Mastaglia
Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·G SchiliroG Russo
Jan 1, 1996·Comparative Immunology, Microbiology and Infectious Diseases·R Cooray
Mar 1, 1983·Veterinary Immunology and Immunopathology·G S Smith, J H Lumsden
Apr 1, 1987·Mutation Research·A B Weitberg
Mar 1, 1989·American Journal of Otolaryngology·T ShimizuY Sakakura
Feb 1, 1985·Burns, Including Thermal Injury·M H el-FalakyA H Houtah
Apr 1, 1995·Free Radical Biology & Medicine·M B Hampton, C C Winterbourn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.