In vitro bactericidal effect of a beta-lactam+aminoglycoside combination against multiresistant Pseudomonas aeruginosa and Acinetobacter baumannii

Journal of Chemotherapy
M Roussel-DelvallezRené Courcol

Abstract

Pseudomonas aeruginosa and Acinetobacter baumannii are frequently isolated in hospital outbreaks of nosocomial infections. In our hospital, among 1018 strains isolated one year in an intensive care unit, 84 strains (8.3%) of P. aeruginosa and 155 strains (15.2%) of A. baumannii were considered responsible for infections. The major problem related to these bacteria is their multiresistant characteristic which confers great difficulty in treating infections. We carried out a 24 h time-kill study to assess the bactericidal effect of three beta-lactams [imipenem (IPM), ticarcillin+clavulanic acid (TCC), piperacillin+tazobactam (PTB)] in combination with each other and with sulbactam (SUL) and amikacin (AKN) against 8 P. aeruginosa strains and 8 A. baumannii strains. The initial inoculum was 10(6) cfu/ml. Antibiotics were tested at clinically achievable concentrations: TCC (112 mg/l), PTB (100 mg/l), IPM (25 mg/l) and AKN (15 mg/l). The results showed: IMP + TCC + AKN = PTB + SUL + AKN = PTB + TCC + AKN > > IMP + SUL + AKN against P. aeruginosa; and PTB + SUL + AKN = PTB + TCC + AKN > IMP + SUL + AKN or IMP + TCC + AKN against A. baumannii. When infection due to these multiresistant strains was suspected, PTB + AKN combined with eit...Continue Reading

References

Jul 1, 1991·The Journal of Antimicrobial Chemotherapy·K Sato, T Nakae
Dec 1, 1991·The Journal of Antimicrobial Chemotherapy·M Obara, T Nakae
Apr 1, 1993·The Journal of Antimicrobial Chemotherapy·X Y ZhouL Gutmann
May 1, 1993·Antimicrobial Agents and Chemotherapy·P NordmannR Labia

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Citations

Jul 16, 2008·Clinical Microbiology Reviews·Anton Y PelegDavid L Paterson
Apr 16, 2021·International Journal of Antimicrobial Agents·Luigia ScudellerEvelina Tacconelli

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