In vitro beneficial activation of microglial cells by mechanically-injured astrocytes enhances the synthesis and secretion of BDNF through p38MAPK

Neurochemistry International
Hao YangSiwei You

Abstract

It has long been promulgated that microglial cells serve beneficial roles in the central nervous system (CNS). The beneficial role of microglial cells is considered to be linked with microglial activation and consequent up-regulation of various trophic factors. However, what triggers microglial activation and consequent elevated level of trophic factors, especially brain-derived neurotrophic factor (BDNF), following traumatic CNS injury has become a crucial but elusive issue. Furthermore, an effort still remains in understanding of the cellular and molecular mechanisms underlying the endogenous neuroprotection of activated microglial cells. In this study, we demonstrated that mechanically-injured astrocyte conditioned medium (ACM) could provoke beneficial activation of microglial cells and thus promote the transcription, synthesis and release of BDNF in cultured microglial cells. The microglia-derived BDNF can exerted a demonstrable biological role in promoting neurite outgrowth and intimate terminal contacts of dorsal root ganglion (DRG) neurons co-cultured with microglial cells. Moreover, ACM induced remarkable p38MAPK phosphorylation in cultured microglial cells that preceded the burst of BDNF. Activating p38-MAPK by anisomy...Continue Reading

References

Jan 1, 1997·Journal of Neuroscience Research·A G Rabchevsky, W J Streit
Oct 23, 1997·Brain Research. Molecular Brain Research·R R HicksK B Seroogy
Oct 20, 1998·Journal of Neuroscience Research·S ElkabesI B Black
Aug 9, 2001·Journal of Neuroscience Research·K NakajimaT Kurihara
Oct 5, 2001·Nature Reviews. Neuroscience·S M Allan, N J Rothwell
Feb 8, 2002·Molecular Neurobiology·A G Yakovlev, A I Faden
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
Sep 3, 2003·Nature Reviews. Drug Discovery·Sanjay KumarJohn C Lee
Mar 20, 2004·Nature Reviews. Drug Discovery·Kevin J BarnhamAshley I Bush
May 19, 2004·Journal of Neurochemistry·Christina M LibertoS W Levison
Jun 9, 2004·Journal of Neuroscience Methods·Amit ShahBetty F Sisken
Sep 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D BalschunH O Besedovsky
Dec 21, 2004·Journal of Molecular Histology·Catherine P RileyCharles R Buck
Feb 25, 2005·Neurological Research·Zhen Zheng, Midori A Yenari
Mar 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mélanie Lalancette-HébertJasna Kriz
Nov 2, 2007·Molecular Pain·Ru-Rong Ji, Marc R Suter
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Wolfgang J StreitEmalick Njie
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lauriane UlmannFrancois Rassendren
Dec 17, 2008·Current Pharmaceutical Design·Antonino Tuttolomondo
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kate Lykke LambertsenBente Finsen
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tuan TrangMichael W Salter
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sohila ZadranMichel Baudry
Mar 26, 2010·Molecular Neurodegeneration·Xiao-Guang LuoSheng-Di Chen

❮ Previous
Next ❯

Citations

Dec 13, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Mahmoud L SolimanThad A Rosenberger
Aug 11, 2012·Neurochemical Research·Jin A ShinEun-Mi Park
Aug 19, 2014·International Journal of Cardiology·Jun-Hee HongGoo-Bo Jeong
Dec 9, 2014·Brain Research·Thomas J Nelson, Daniel L Alkon
May 3, 2014·Neuroscience·L Peruzzotti-JamettiS Pluchino
Sep 2, 2017·Journal of Neuropathology and Experimental Neurology·Charanjit KaurEng-Ang Ling
Oct 8, 2015·Translational Neuroscience·Wenhui ShiLi-Cai Zhang
Mar 4, 2017·Lasers in Medical Science·Camila da Luz EltchechemRodolfo Borges Parreira
Aug 23, 2019·International Journal of Molecular Sciences·George Anderson, Gianluigi Mazzoccoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.