PMID: 2495837Feb 27, 1989Paper

In vitro binding of [14C]acrylamide to neurofilament and microtubule proteins of rats

Brain Research
D M LapadulaM B Abou-Donia

Abstract

Acrylamide produces a dying back type of neuropathy in which there is an accumulation of neurofilaments in the axons. The in vitro binding of [14C]acrylamide to neurofilament and microtubule proteins obtained from rat spinal cord and brain was investigated. The relative binding to the high and middle molecular weight neurofilament was greater than to the low molecular weight neurofilament, while the rate of binding to MAP-1 (microtubule associated protein-1) and -2 was much greater than to tubulin. The binding rate to a 53 kDa protein which co-purified with the neurofilaments was between those of the middle and high molecular weight neurofilaments while the lowest rate of binding was to glial fibrillary acidic protein. These data indicate that there is a direct binding of acrylamide to cytoskeletal proteins.

References

Jan 1, 1985·Annual Review of Biochemistry·D W Cleveland, K F Sullivan
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M L ShelanskiC R Cantor
Sep 1, 1970·Biochemical Pharmacology·K Hashimoto, W N Aldridge
Jan 1, 1982·Journal of Neurochemistry·R A Hogue-AngelettiW W Schlaepfer

❮ Previous
Next ❯

Citations

Apr 23, 2002·Journal of Cellular Biochemistry·Wen-Hsin HoHsiang-Shu Yin
Sep 1, 1994·Neurochemical Research·C L LanningM B Abou-Donia
Jun 1, 1991·Journal of the Autonomic Nervous System·V RalevicG Burnstock
Jan 1, 1991·Neurochemistry International·C D CarringtonM B Abou-Donia
Aug 8, 2002·Neurotoxicology·R M LoPachinE J Lehning
Sep 13, 2002·Neurotoxicology·Dale W SicklesMarvin A Friedman
Oct 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Nordin-AnderssonE Walum
Aug 1, 1993·Journal of Toxicology and Environmental Health·S PadillaA C Breuer
Aug 1, 1993·Journal of Toxicology and Environmental Health·M B Abou-DoniaD M Lapadula
Apr 1, 1993·Mutation Research·I D AdlerE Schmid
Apr 1, 1997·Molecular and Chemical Neuropathology·R P Gupta, M B Abou-Donia
Sep 9, 2008·Regulatory Toxicology and Pharmacology : RTP·Michael DoursonMelissa Kohrman
Oct 12, 2004·Toxicology Letters·Jeffery S LaffertyJames E Klaunig
Jan 3, 2006·Mutation Research·Naoki KoyamaMasamitsu Honma
May 12, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jong-Hang Chen, Chin-Cheng Chou
Feb 23, 2010·Critical Reviews in Toxicology·Janneke G F HogervorstPiet A van den Brandt
Apr 14, 2017·International Journal of Toxicology·Leslie RecioNikolai L Chepelev
Sep 16, 2006·Critical Reviews in Toxicology·A ShippC Van Landingham

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.