PMID: 39167Feb 1, 1979

In vitro binding of Trypanosoma congolense to erythrocytes

The Journal of protozoology
K L Banks

Abstract

Trypanosoma congolense Broden, an intravascular parasite, binds to vessel walls and erythrocytes of infected hosts. In an attempt to characterize T. congolense adhesion to host cells, an in vitro assay was devised. It was shown in the in vitro experiments that T. congolense binds to bovine, sheep, and goat erythrocytes, but not always to erythrocytes of rats, mice, rabbits, horses or humans. Only the anterior part of live trypanosomes adheres to erythrocytes, and the attachment site on the trypanosomes is destroyed by trypsin and chymotrypsin-trypanosomes did not adhere to bovine erythrocytes that had been incubated with neuraminidase, sodium periodate and poly-L-lysine. The foregoing experiments suggest that the surface of T. congolense contains a protein-associated site which binds to sialic acid of some host cells. This surface site is most likely responsible for attachment to blood vessels in vivo.

References

Sep 1, 1984·Veterinary Parasitology·K A EsievoO O Adegoke
Mar 26, 1998·International Journal for Parasitology·K A Taylor
Dec 1, 1994·Parasitology·A HemphillC A Ross
Jan 27, 2009·Infection and Immunity·Nicolas Antoine-MoussiauxDaniel Desmecht
Mar 9, 2010·PLoS Neglected Tropical Diseases·Virginie CoustouThéo Baltz
Nov 26, 2004·The Journal of Parasitology·Dennis J GrabKwang Sik Kim
Oct 11, 2016·Parasitology·Federica GiordaniMichael P Barrett
Jan 1, 1986·Journal of Comparative Pathology·K A EsievoL O Eduvie

Related Concepts

Nannomonas
Blood Vessel
Bos taurus
Sialic Acid Assay
Lysine
Trypsin
Neuraminidase
Staphylococcal Protein A
Trypanosoma congolense
Binding (Molecular Function)

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