In vitro bioaccessibility of the marine biotoxin okadaic acid in shellfish

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Ana C BragaPedro R Costa

Abstract

Okadaic acid (OA) and their derivatives are marine toxins responsible for the human diarrhetic shellfish poisoning (DSP). To date the amount of toxins ingested in food has been considered equal to the amount of toxins available for uptake by the human body. In this study, the OA fraction released from the food matrix into the digestive fluids (bioaccessibility) was assessed using a static in vitro digestion model. Naturally contaminated mussels (Mytilus galloprovincialis) and donax clams (Donax sp.), collected from the Portuguese coast, containing OA and dinophysistoxin-3 (DTX3) were used in this study. Bioaccessibility of OA total content was 88% and 75% in mussels and donax clams, respectively. Conversion of DTX3 into its parent compound was verified during the simulated digestive process and no degradation of these toxins was found during the process. This is the first study assessing the bioaccessibility of OA-group toxins in naturally contaminated seafood. This study provides relevant new data that can improve and lead to more accurate food safety risk assessment studies concerning these toxins.

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Citations

Jul 28, 2016·Frontiers in Microbiology·Pierina ViscianoGiovanna Suzzi
Aug 6, 2020·Toxins·Alexandre CamposPedro Reis Costa
Aug 12, 2018·Toxins·Natalia VilariñoLuis M Botana
May 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Leticia Díez-Quijada JiménezAna M Cameán
Mar 10, 2020·Toxicon : Official Journal of the International Society on Toxinology·Mauro CorriereLucía Soliño

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