In vitro biocompatibility evaluation of bioresorbable copolymers prepared from L-lactide, 1, 3-trimethylene carbonate, and glycolide for cardiovascular applications

Journal of Biomaterials Science. Polymer Edition
Xin ShenSuming Li

Abstract

PLLA-TMC-GA terpolymer was prepared by ring-opening polymerization of L-lactide, 1, 3-trimethylene carbonate (TMC), and glycolide (GA). The biocompatibility of terpolymer was evaluated in comparison with PLLA and PLLA-TMC with the aim of assessing their potential in the development of bioresorbable cardiovascular stents. Various aspects of in vitro biocompatibility were considered, including MTT assay, hemolytic test, dynamic clotting time, platelet adhesion, platelet activation, protein adsorption, plasma recalcification time and release of cytokines. The results revealed that the terpolymer presents good cytocompatibility and hemocompatibility. Moreover, no significant increase in the release of cytokines was detected. It is thus concluded that these polymers, in particular PLLA-TMC-GA terpolymer present good biocompatibility for cardiovascular applications.

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Citations

Aug 3, 2017·Journal of Biomedical Materials Research. Part a·Li LuXie Congxia
Nov 11, 2019·Applied Biochemistry and Biotechnology·Qingxi HuHaiguang Zhang
Mar 27, 2020·Scientific Reports·Evgeny A OvcharenkoLeonid S Barbarash
Jan 31, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Xin ShenSuming Li

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Methods Mentioned

BETA
scanning electron microscopy
enzyme-linked immune sorbent assay
ELISA
PMA

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