In vitro biocompatibility of PTMO-based polyurethanes and those containing PDMS blocks

Journal of Biomaterials Applications
Shan-Hui Hsu, Hsiang-Jung Tseng

Abstract

In this work, a series of different polyurethanes based on poly(tetramethylene oxide) (PTMO, MW approximately 2000) and chain extended with butenediol were synthesized by a two-step solution polymerization. Three of them contained silanol terminated polydimethylsiloxane (PDMS, MW approximately 2000) blocks. It was shown that these polymers exhibited various degrees of micro-phase separation that further influenced their biological performances in vitro. The formulation with diphenylmethane diisocyanate/PTMO/PDMS/2-butene-1,4-diol at a molar ratio of 2: 0.75: 0.5: 1 in synthesis was favorable due to a combination of enhanced mechanical properties, biostability, cellular affinity as well as platelet nonadherence.

References

Oct 1, 1992·Journal of Biomaterials Applications·C D Capone
Mar 1, 1991·Journal of Biomedical Materials Research·A TakaharaS L Cooper
Jun 1, 1994·Biomaterials·R W HergenrotherS L Cooper
Jan 1, 1994·Journal of Biomaterials Applications·A M ReedM Szycher
Oct 1, 1995·Journal of Biomaterials Applications·A EdwardsW C Quist
Apr 1, 1995·Journal of Biomaterials Applications·K StokesJ M Anderson
Oct 29, 2003·Biomaterials·M J DalbyA S G Curtis

❮ Previous
Next ❯

Citations

May 2, 2012·IEEE Transactions on Bio-medical Engineering·Michal Karol DobrzynskiDario Floreano
Jul 20, 2011·Journal of Polymer Science. Part B, Polymer Physics·Bret D UleryCato T Laurencin
May 29, 2010·Journal of Biomaterials Science. Polymer Edition·Yan-Ling LuoPei Zhao
Dec 31, 2011·Journal of Biomaterials Applications·Parth N Shah, Yang H Yun
Mar 16, 2013·Advanced Healthcare Materials·Peiyi SongKen-Tye Yong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.