In vitro biosynthesis of the antitumor agent azinomycin B

Organic Letters
Chaomin LiuCoran M H Watanabe

Abstract

[reaction: see text] Azinomycins have potential therapeutic value as antitumor agents; however, their biosynthesis is poorly understood. Here, we provide the first demonstration of a protein cell-free system capable of supporting complete in vitro biosynthesis of the antitumor agent azinomycin B. The cell-free system is utilized to probe the cofactor dependence and substrate requirements of the pathway en route to azinomycin.

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Citations

Oct 25, 2011·Chemical Reviews·Christopher J ThibodeauxHung-wen Liu
Nov 26, 2009·Journal of the American Chemical Society·Yasushi Ogasawara, Hung-wen Liu
Oct 17, 2014·Biotechnology Journal·Quentin M DudleyMichael C Jewett
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Apr 1, 2018·Applied Microbiology and Biotechnology·Xihong HeHuitu Zhang
Feb 18, 2011·Natural Product Reports·Jennifer Foulke-AbelCoran M H Watanabe
Sep 13, 2017·Applied Microbiology and Biotechnology·Yang LiuHuitu Zhang
Jan 31, 2021·Carbohydrate Research·Banty KumarAshok K Prasad
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Jan 31, 2017·Biochemistry·Shogo MoriCoran M H Watanabe
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Sep 11, 2007·The Journal of Organic Chemistry·Robert S ColemanDaniel J Carper

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