PMID: 9004196Dec 1, 1996Paper

In-vitro bronchorelaxing effects of novel nitric oxide donors GEA 3268 and GEA 5145 in guinea-pigs and rats

The Journal of Pharmacy and Pharmacology
K VaaliH Vapaatalo

Abstract

Endogenously released nitric oxide (NO) in airways might contribute to physiological bronchodilation; induced production of NO might play a role in the pathogenesis of asthma, although it could also be a compensatory mechanism to other factors that cause bronchoconstriction or inflammation. To investigate the efficacy of NO donors on bronchial tone, the bronchorelaxing efficacies of NO donors, new experimental GEA compounds 3268 and 5145 (oxatriazole sulphonylamides) were compared with those of sodium nitroprusside and SIN-1 (3-morpholinosydnonimine) and to the standard beta 2-adrenergic agonist, salbutamol, in bronchi of guinea-pigs and rats in-vitro. Their relaxing effects were also studied in rat mesentery arteries to compare the selectivity for airways. The capacity of the NO donors to produce nitrites and nitrates was assayed by the Griess reaction. The novel NO donors GEA 3268 and GEA 5145 were more potent bronchorelaxing agents than the old NO donors sodium nitroprusside and SIN-1. In guinea-pig bronchi, however, salbutamol was most potent. In rat bronchi the GEA compounds induced the strongest relaxation effect when compared with the old NO donors or with salbutamol. The airway selectivity of the drugs studied decreased...Continue Reading

References

Jan 14, 1992·European Journal of Pharmacology·M G BelvisiP J Barnes
Jan 1, 1992·British Medical Bulletin·P J Barnes
May 1, 1989·The American Review of Respiratory Disease·C A GruetterM A Valentovic
Apr 28, 1989·Biochemical and Biophysical Research Communications·C D WrightH Osswald
Apr 1, 1982·Acta Physiologica Scandinavica·M Vornanen
Feb 15, 1994·Biochemical and Biophysical Research Communications·R A RobbinsJ Polak
Feb 26, 1993·Biochemical and Biophysical Research Communications·B JainJ H Sisson
Oct 1, 1993·Thorax·P J Barnes, M G Belvisi
Jul 1, 1993·British Journal of Pharmacology·E MoilanenH Vapaatalo
Feb 1, 1996·British Journal of Pharmacology·H KankaanrantaT Metsä-Ketelä

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Citations

May 19, 2005·European Journal of Pharmacology·Britt ElmedalUlf Simonsen
Sep 24, 2002·Pharmacology & Therapeutics·B J Nevin, K J Broadley
Feb 26, 1999·Journal of Neurochemistry·A I BoullerneJ A Benjamins

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