In Vitro Carcinoma Treatment Using Magnetic Nanocarriers under Ultrasound and Magnetic Fields

ACS Omega
Somoshree SenguptaVamsi K Balla

Abstract

Nowadays, tumor hypoxia has become a more predominant problem for diagnosis as well as treatment of cancer due to difficulties in delivering chemotherapeutic drugs and their carriers to these regions with reduced vasculature and oxygen supply. In such cases, external physical stimulus-mediated drug delivery, such as ultrasound and magnetic fields, would be effective. In this work, the effect of simultaneous exposure of low-intensity pulsed ultrasound and static magnetic field on colon (HCT116) and hepatocellular (HepG2) carcinoma cell inhibition was assessed in vitro. The treatment, in the presence of anticancer drug, with and without magnetic carrier, significantly increased the reactive oxygen species production and hyperpolarized the cancer cells. As a result, a significant increase in cell inhibition, up to 86%, was observed compared to 50% inhibition with bare anticancer drug. The treatment appears to have relatively more effect on HepG2 cells during the initial 24 h than on HCT116 cells. The proposed treatment was also found to reduce cancer cell necrosis and did not show any inhibitory effect on healthy cells (MC3T3). Our in vitro results suggest that this approach has strong application potential to treat cancer at lowe...Continue Reading

References

Sep 1, 1988·Mutation Research·J R Savage, R Prasad
Jul 1, 1965·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·G C Whittow
May 5, 1999·Lancet·K TachibanaK Tamura
Feb 24, 2001·Medical & Biological Engineering & Computing·A MontalibetD Cathignol
Sep 6, 2001·Bioelectromagnetics·S TofaniF Ronchetto
Mar 30, 2004·Biochemical Society Transactions·K OkkenhaugB Vanhaesebroeck
Jul 1, 2005·Physiological Reviews·Colin D McCaigMin Zhao
Dec 13, 2005·The Journal of the Acoustical Society of America·Yunbo LiuPei Zhong
Mar 11, 2006·Apoptosis : an International Journal on Programmed Cell Death·L GhibelliL M Porfiri
Mar 21, 2006·Biochemical and Biophysical Research Communications·Richard NuccitelliKarl H Schoenbach
Apr 5, 2007·British Journal of Cancer·S Sengupta, R Sasisekharan
Jun 27, 2007·Journal of Pharmaceutical Sciences·Tomris Ozben
Nov 14, 2007·Methods in Enzymology·J Martin Brown
Nov 21, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M Christiane Brahimi-HornJacques Pouysségur
Jul 10, 2008·Molecular Pharmaceutics·Shyh-Dar Li, Leaf Huang
Aug 30, 2008·Ultrasound in Medicine & Biology·Douglas L Miller, Chunyan Dou
Dec 19, 2009·Cell Death and Differentiation·I K H PoonC R Parish
Jun 10, 2010·Journal of Cell Science·Gabi Gerlitz, Michael Bustin
Aug 17, 2010·Cancer Biotherapy & Radiopharmaceuticals·Wen-Fang ChenJian-Qiang Liu
Oct 19, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshimi HaradaKatsuro Tachibana
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Beata ChertokVictor C Yang
Jul 22, 2011·Nature·Brenton D HoffmanMartin A Schwartz
Jul 28, 2011·NMR in Biomedicine·Reut AvniMichal Neeman
Sep 29, 2011·Journal of Radiation Research·Hiroshi Harada
Jan 1, 2010·Nano Reviews·Meng Meng LinDo Kyung Kim
Aug 1, 2012·International Journal of Nanomedicine· Wahajuddin, Sumit Arora
Nov 6, 2012·Expert Opinion on Drug Delivery·Steven MoRobert Carlisle
Jan 22, 2013·Ultrasound in Medicine & Biology·Dana GourevichAndreas Melzer
Feb 26, 2013·Journal of the National Cancer Institute·Jean-Pierre GilletMichael M Gottesman
Jun 29, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mahnaz MahdaviJamileh Amin
Jul 10, 2013·Ultrasonics Sonochemistry·Mikhail A BuldakovTakashi Kondo
Jul 25, 2013·Frontiers in Physiology·Ming Yang, William J Brackenbury
Sep 13, 2013·BioMed Research International·Soumaya GhodbaneHafedh Abdelmelek
Dec 18, 2013·Experimental Dermatology·Richard NuccitelliErvin H Epstein
Jun 1, 2014·International Journal of Radiation Oncology, Biology, Physics·Giovanni BorasiMaria Carla Gilardi
Jul 19, 2014·Journal of Pharmacy & Bioallied Sciences·Kanika MadaanDeepti Pandita
Apr 14, 2015·International Journal of Molecular Sciences·Joan EstelrichMaria Antònia Busquets
Oct 28, 2015·Advanced Pharmaceutical Bulletin·Neda NaseriParvin Zakeri-Milani

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
dynamic laser
Transmission electron microscopy
dynamic light scattering
ELISA
Assay

Software Mentioned

ImageJ

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.