In vitro cellular adhesion and antimicrobial property of SiO2-MgO-Al2O3-K2O-B2O3-F glass ceramic.

Journal of Materials Science. Materials in Medicine
Sushma KalmodiaBikramjit Basu

Abstract

The aim of the present study was to examine the cellular functionality and antimicrobial properties of SiO(2)-MgO-Al(2)O(3)-K(2)O-B(2)O(3)-F glass ceramics (GC) containing fluorophlogopite as major crystalline phase. The cellular morphology and cell adhesion study using human osteoblast-like Saos-2 cells and mouse fibroblast L929 cells reveals good in vitro cytocompatibility of GC. The potential use of the GC for biomedical application was also assessed by in vitro synthesis of the alkaline phosphatase (ALP) activity of Saos-2 cells. It is proposed that B(2)O(3) actively enhances the cell adhesion and supports osteoconduction process, whereas, fluorine component significantly influences cell viability. The Saos-2 and L929 cells on GC shows extensive multidirectional network of actin cytoskeleton. The in vitro results of this study illustrate how small variation in fluorine and boron in base glass composition influences significantly the biocompatibility and antimicrobial bactericidal property, as evaluated using a range of biochemical assays. Importantly, it shows that the cell viability and osteoconduction can be promoted in glass ceramics with lower fluorine content. The underlying reasons for difference in biological propert...Continue Reading

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Citations

Nov 21, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Siddhi GuptaArvind Sinha
Aug 21, 2013·Biomaterials·Davide CampocciaCarla Renata Arciola
Apr 8, 2014·Acta Biomaterialia·Ourania-Menti GoudouriAldo R Boccaccini
Aug 25, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Xiao LinLei Yang
Oct 27, 2016·Journal of Biomedical Materials Research. Part a·Julian BejaranoHumberto Palza

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