PMID: 6979161Apr 1, 1982Paper

In vitro changes in cell mediated immunity following tuberculin skin testing in humans

Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology
J R Jensen, K Threstrup-Pedersen

Abstract

Tuberculin skin testing with purified protein derivative (PPD) was found to induce alterations of in vitro measures of cell mediated immunity. T lymphopenia with proportionate decreases of TM and TG cell numbers were observed two days after skin testing. A relative augmentation of TM cells was demonstrated after one week. Peripheral blood mononuclear cells from negative skin responders had normal in vitro reactivity to PPD stimulation suggesting a cutaneous abberation in these individuals. Macrophage dependent depressed PHA reactivity of mononuclear cells was demonstrated two days after skin testing. No change in natural killer cell cytotoxicity was observed. Cytotoxicity was positively correlated to the number of TG cells in the assay.

References

Jan 1, 1978·Scandinavian Journal of Immunology·T NagaokiN Taniguchi
Jan 1, 1979·Scandinavian Journal of Immunology·B O Bergholtz, E Thorsby
Jul 1, 1974·Journal of Immunological Methods·M E Kaplan, C Clark
Dec 17, 1964·The New England Journal of Medicine·J A BRODYL M HAMMES
Sep 1, 1971·The Journal of Experimental Medicine·S F SchlossmanJ R David

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