In vitro characterisation of zirconia coated by bioactive glass

Biomaterials
M BosettiM Cannas

Abstract

An in vitro evaluation of a biomedical device, which combines the mechanical properties of zirconia substrates with the bioactivity of two different glass layers (AP40 and RKKP), was performed. In this work, data on different kinds of analysis were reported both on as-sintered zirconia samples and on RKKP- and AP40-coated zirconia substrates. Structure, composition and morphology of the apatite layer growth on the coated samples after 30 days of soaking in an acellular simulated body fluid, serum protein adsorption, fibroblasts and human osteoblast-like cells adhesion, growth, morphology and biochemical aspects were studied. Results of soaking test in SBF, revealed the growth of an apatite layer on the surface of the glass-coated samples. Proteins adsorbed to the materials were analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and results evidenced that the two glass-coated materials bound a higher amount of total protein than did the zirconia substrate. Fibroblasts and osteoblast-like cells cultured on RKKP- and AP40-coated zirconia showed a higher proliferation rate, leading to confluent cultures with higher cell density and a generally better expression of osteoblast alkaline phosphatase activity in comp...Continue Reading

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Citations

Dec 17, 2002·Journal of Biomedical Materials Research. Part a·Michela BosettiMario Cannas
Sep 17, 2005·Journal of Materials Science. Materials in Medicine·C Vitale-BrovaroneM Cannas
Mar 4, 2005·Journal of Materials Science. Materials in Medicine·A KrajewskiM Fini
Jun 5, 2007·Journal of Materials Science. Materials in Medicine·M BosettiM Cannas
May 8, 2007·Journal of Materials Science. Materials in Medicine·Johan MalmströmPeter Thomsen
Dec 25, 2007·Journal of Materials Science. Materials in Medicine·Mohamed N RahamanWenhai Huang
Apr 10, 2013·Acta Biomaterialia·Laura TreccaniKurosch Rezwan
Nov 6, 2002·Biomaterials·A RosengrenA Ravaglioli
Jul 24, 2013·International Journal of Biomaterials·Jabr S Al-SanabaniFadhel A Al-Sanabani
Aug 7, 2003·Journal of Biomaterials Science. Polymer Edition·O Aylin GürpinarErhan Pişkin
Feb 19, 2015·Journal of Bone and Mineral Metabolism·Michela BosettiMario Cannas
Feb 28, 2007·Journal of Biomedical Materials Research. Part a·Ugo CovaniClaudio Nicolini
May 12, 2010·Journal of Cellular Physiology·Michela BosettiMario F Cannas
Jun 30, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Juliana MarchiMárcia M Marques
Mar 26, 2016·International Journal of Biological Macromolecules·S DeepthiR Jayakumar
Aug 15, 2003·Journal of Biomedical Materials Research. Part a·M BosettiM Cannas
Oct 5, 2011·International Journal of Biological Macromolecules·Soumitri PattnaikNagarajan Selvamurugan
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Emad M M EwaisKurosch Rezwan
Dec 9, 2016·Dental Materials Journal·Maryam MoezzizadehHaleh Valizadeh Haghi
Jun 14, 2019·Dental Materials Journal·Mao YamadaHiroshi Murata

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