In vitro characteristics of metastatic variant subclones of restricted genetic origin

Journal of Supramolecular Structure and Cellular Biochemistry
J E TalmadgeD R Stanford

Abstract

We have studied several metastatic variant cell lines derived from a common clonal origin and their transformed and untransformed parental cell lines. A number of in vitro characteristics were examined for each tumor line and these properties were correlated with the ability of the tumor cells to form pulmonary nodules in an experimental metastasis assay. Direct correlations with metastatic behavior in the lung colony assay were found to exist with the amount of cell-bound Concanavalin A and the procoagulant activities of cell lysates. In vitro parameters that did not correlate with the metastatic phenotype were: population doubling times in culture, saturation density achieved in culture, the number of colony-forming cells shed from confluent cultures, rates of cellular attachment to homotypic or heterotypic cell monolayers, plasminogen-activator production and procoagulant activity produced in serum-free conditioned medium.

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Citations

Jan 1, 1983·Cancer Metastasis Reviews·J E Talmadge
Jan 1, 1985·Cancer Metastasis Reviews·I A Ramshaw, P Badenoch-Jones
Jan 1, 1982·Cancer Metastasis Reviews·G Poste
Jan 1, 1983·Cancer Metastasis Reviews·M W Kieran, B M Longenecker
Apr 15, 1986·Experientia·P Badenoch-JonesA Grant
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Oct 15, 1984·International Journal of Cancer. Journal International Du Cancer·J R StarkeyH L Hosick
Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·J G SteeleL M Franks

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