In vitro characterization of 3D printed scaffolds aimed at bone tissue regeneration

Colloids and Surfaces. B, Biointerfaces
João C BogaI J Correia

Abstract

The incidence of fractures and bone-related diseases like osteoporosis has been increasing due to aging of the world's population. Up to now, grafts and titanium implants have been the principal therapeutic approaches used for bone repair/regeneration. However, these types of treatment have several shortcomings, like limited availability, risk of donor-to-recipient infection and tissue morbidity. To overcome these handicaps, new 3D templates, capable of replicating the features of the native tissue, are currently being developed by researchers from the area of tissue engineering. These 3D constructs are able to provide a temporary matrix on which host cells can adhere, proliferate and differentiate. Herein, 3D cylindrical scaffolds were designed to mimic the natural architecture of hollow bones, and to allow nutrient exchange and bone neovascularization. 3D scaffolds were produced with tricalcium phosphate (TCP)/alginic acid (AA) using a Fab@home 3D printer. Furthermore, graphene oxide (GO) was incorporated into the structure of some scaffolds to further enhance their mechanical properties. The results revealed that the scaffolds incorporating GO displayed greater porosity, without impairing their mechanical properties. These s...Continue Reading

Citations

Sep 24, 2019·The International Journal of Artificial Organs·Željka Perić KačarevićMike Barbeck
Oct 26, 2018·International Journal of Molecular Sciences·Patrick RiderMike Barbeck
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Chrysanthi-Maria MoysidouRóisín Meabh Owens
Apr 16, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Zhiyi ZhangSheng Yang
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Courtney R LynchYahya E Choonara
Jun 7, 2021·Trends in Molecular Medicine·Fiona E FreemanDaniel J Kelly

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