PMID: 9443670Jan 27, 1998Paper

In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir)

Antiviral Research
X XiongJ M Cherrington

Abstract

PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials. PMEA diphosphate (PMEApp), the active antiviral metabolite of PMEA, is a potent inhibitor of human cytomegalovirus (HCMV) DNA polymerase. PMEA is efficiently taken up and phosphorylated to PMEApp in numerous human cell lines. In vitro replication of wild type and drug resistant HCMV clinical isolates is effectively inhibited by PMEA. PMEA in combination with other anti-HCMV agents shows additive inhibition of HCMV replication.

References

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Citations

Dec 2, 1998·Antiviral Research·M D de JongS A Spector
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S Chou
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yves Benhamou
Aug 25, 2004·Gastroenterology Clinics of North America·Yves Benhamou, Luminita Bonyhay
Jul 22, 2005·The Journal of General Virology·G M ScottW D Rawlinson

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