PMID: 2505070Sep 1, 1989Paper

In vitro chromosome damage due to PCB interactions

Mutation Research
L SargentL F Meisner

Abstract

In order to study the possible mutagenic properties of polychlorinated biphenyls (PCBs), human lymphocyte cultures were examined for chromosome breakage, rearrangements, sister-chromatid exchange, and mitotic delay. The present study, which used cyclophosphamide as a positive control, shows that one planar PCB congener, 3,4,3',4'-tetrachlorobiphenyl, caused dose-related chromosome breakage in human lymphocytes exposed in vitro to 0.1-10(-4) micrograms/ml. In contrast, the non-planar PCB, 2,5,2',5', did not cause chromosome damage in comparable tests even at concentrations as high as 1 microgram/ml. However, when 3,4,3',4' at a concentration lower than that which causes chromosome breakage (10(-5) micrograms/ml) was combined with a non-clastogenic concentration of 2,5,2',5', the chromosomal damage observed was far in excess of what one would expect from higher doses of 3,4,3',4' alone. These results suggest that some PCB congeners may interact to cause synergistic genotoxic effects.

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Citations

Sep 14, 2012·Journal of Molecular Modeling·Soraya AbtoucheXavier Assfeld
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J T Borlakoglu, K D Haegele
Dec 6, 2012·Cancer Letters·Gabriele Ludewig, Larry W Robertson
Jan 22, 1998·Mutation Research·J B BishopR A Sloane
Feb 14, 2003·Toxicology and Applied Pharmacology·Parvaneh EspandiariLarry W Robertson
Apr 15, 2003·Toxicology and Applied Pharmacology·Jürgen BorlakElmar Richter
May 1, 1995·Environmental Health Perspectives·P MendolaL E Sever
Jun 25, 2008·Mutation Research·Suleyman SandalDavid O Carpenter
Jun 30, 2009·Environmental Toxicology·Weihong HeXuemin Chen
Aug 21, 2003·Environmental and Molecular Mutagenesis·Maria G EvandriPaola Bolle
Oct 20, 2006·Critical Reviews in Toxicology·Stefanie Knerr, Dieter Schrenk
Jan 1, 1990·Critical Reviews in Toxicology·E M SilberhornL W Robertson
Feb 5, 2019·Toxicology Mechanisms and Methods·Okunola A AlabiYetunde M Adeoluwa
Dec 22, 2016·Molecular Medicine Reports·Caterina LeddaVenerando Rapisarda
Jul 27, 2017·Environmental Science and Pollution Research International·Kiran DhakalLarry W Robertson

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