In vitro comet and micronucleus assays do not predict morphological transforming effects of silica particles in Syrian Hamster Embryo cells

Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Christian DarneYves Guichard

Abstract

Crystalline silica particles and asbestos have both been classified as carcinogenic by the International Agency for Research on Cancer (IARC). However, because of the limited data available, amorphous silica was not classifiable. In vitro, the carcinogenic potential of natural crystalline and amorphous silica particles has been revealed by the Syrian Hamster Embryo (SHE) cell transformation assay. On the other hand, the genotoxic potential of those substances has not been investigated in SHE cells. And yet, genotoxicity assays are commonly used for hazard evaluation and they are often used as in vitro assays of reference to predict a possible carcinogenic potential. The main objective of this study was to compare the genotoxic potential and the carcinogenic potential of different crystalline and amorphous silica particles in SHE cells. Three silica samples of different crystallinity were used: natural amorphous silica, partially crystallized silica and quartz silica particles. Their genotoxicity were tested through the in vitro micronucleus assay and the comet assay in SHE, and their carcinogenic potential through the SHE transformation assay. In addition, silica samples were also tested with the same genotoxicity assays in V79...Continue Reading

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Citations

Jul 6, 2016·Archives of Toxicology·M GleiW Schlörmann
Oct 1, 2017·Environmental Science and Pollution Research International·Yali ZengYulin Wang
Sep 30, 2017·Nanotoxicology·Carole SeidelYves Guichard
May 23, 2018·Particle and Fibre Toxicology·Paul J A BormDavid Kirkland

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