In vitro comparison of antiviral drugs against feline herpesvirus 1.

BMC Veterinary Research
K van der MeulenH Nauwynck

Abstract

Feline herpesvirus 1 (FHV-1) is a common cause of respiratory and ocular disease in cats. Especially in young kittens that have not yet reached the age of vaccination, but already lost maternal immunity, severe disease may occur. Therefore, there is a need for an effective antiviral treatment. In the present study, the efficacy of six antiviral drugs, i.e. acyclovir, ganciclovir, cidofovir, foscarnet, adefovir and 9-(2-phosphonylmethoxyethyl)-2, 6-diaminopurine (PMEDAP), against FHV-1 was compared in Crandell-Rees feline kidney (CRFK) cells using reduction in plaque number and plaque size as parameters. The capacity to reduce the number of plaques was most pronounced for ganciclovir, PMEDAP and cidofovir. IC50 (NUMBER) values were 3.2 microg/ml (12.5 microM), 4.8 microg/ml (14.3 microM) and 6 microg/ml (21.5 microM), respectively. Adefovir and foscarnet were intermediately efficient with an IC50 (NUMBER) of 20 microg/ml (73.2 microM) and 27 microg/ml (140.6 microM), respectively. Acyclovir was least efficient (IC50 (NUMBER) of 56 microg/ml or 248.7 microM). All antiviral drugs were able to significantly reduce plaque size when compared with the untreated control. As observed for the reduction in plaque number, ganciclovir, PMED...Continue Reading

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Citations

Apr 27, 2010·Journal of Feline Medicine and Surgery·Claudia Hartley
Jul 3, 2013·Journal of Feline Medicine and Surgery·Marian C HorzinekUwe Truyen
Feb 14, 2007·Veterinary Research·Rosalind GaskellEtienne Thiry
Sep 20, 2019·The Journal of Antibiotics·Yudai KurodaKen Maeda
Aug 5, 2020·Journal of Feline Medicine and Surgery·Andrew C LewinRenee T Carter
Apr 20, 2016·Veterinary Ophthalmology·Sara M Thomasy, David J Maggs
Aug 26, 2018·Journal of Fish Diseases·Agnieszka TroszokIlgiz Irnazarow
Jul 22, 2019·Antiviral Research·Aleksandra SynowiecKrzysztof Pyrc
Nov 2, 2021·Journal of Veterinary Pharmacology and Therapeutics·Orhan CorumMuammer Elmas

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Methods Mentioned

BETA
light microscopy

Software Mentioned

Scion
SPSS
MathType

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