PMID: 9192941Jun 1, 1997Paper

In vitro comparison of the amount of salbutamol available for inhalation from different formulations used with different spacer devices

The European Respiratory Journal
P W Barry, C O'Callaghan

Abstract

Metered-dose inhalers (MDIs) are currently being reformulated to contain hydrofluoroalkanes (HFAs), which do not damage the Earth's ozone layer. As different formulations of inhaled drugs may behave differently when used with spacer devices, we wished to determine the amount of salbutamol available for inhalation from a conventional metered-dose inhaler (Ventolin) and a new HFA-containing formulation (Airomir), when used with two different spacers. A glass multistage liquid impinger was used to determine the amount of salbutamol delivered from the inhalers used with the Aerochamber and the Nebuhaler spacer devices. High speed video-recordings of inhaler actuation into air were made, and the speed of the aerosol and the aerosol cloud volume were measured. More salbutamol in small particles (<5 microm) was delivered from the Airomir MDI than the Ventolin MDI, when used with the Aerochamber (40.4 (95% confidence interval (95% CI) 31.2-49.6) versus 19.5 (19.0-20.0) microg) and the Nebuhaler (42.1 (36.3-47.9) versus 24.6 (23.3-25.8) microg). The aerosol cloud from the Airomir MDI was slower than the Ventolin aerosol, and 60 ms after actuation had travelled 186 mm, whereas the Ventolin aerosol had travelled 320 mm. At the same time, ...Continue Reading

Citations

Jan 15, 2005·Pharmaceutical Research·Sylvia VerbanckWalter Vincken
Jul 5, 2003·Advanced Drug Delivery Reviews·P W Barry, C O'Callaghan
Jun 19, 2001·International Journal of Pharmaceutics·J C DubusM Dolovich
Sep 25, 2002·International Journal of Pharmaceutics·R JanssenP Zanen
Jul 25, 2003·International Journal of Pharmaceutics·J C DubusM Badier
Jun 1, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G R DickensS Choudhury
Mar 30, 2007·The New England Journal of Medicine·Leslie HendelesRobert J Meyer
Jun 27, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M B Dolovich
Oct 30, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Y S ChengY Zhou
Feb 13, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Muhib F RahmatallaWarren H Finlay
May 10, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Vijay JoguparthiPaula Anderson
Mar 21, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·W H Finlay, P Zuberbuhler
May 12, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·André SchultzSunalene G Devadason
Dec 23, 1999·Current Opinion in Pulmonary Medicine·R Dhand
Dec 18, 2004·Fundamental & Clinical Pharmacology·J C Dubus, M Dolovich
Mar 13, 2002·Paediatric Drugs·Elizabeth Biggart, Andrew Bush
Nov 16, 2013·Pharmaceutical Research·Irene ParisiniDarragh Murnane
Apr 1, 2008·Expert Review of Respiratory Medicine·Gene L Colice
Feb 25, 2009·Expert Opinion on Drug Delivery·Federico Lavorini, Giovanni A Fontana
Nov 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Vireak VoeurngJean-Christophe Dubus
Apr 15, 2010·Inhalation Toxicology·Ahmed FadlZongqin Zhang
Apr 29, 2008·Clinics in Chest Medicine·Rajiv Dhand, Vamsi P Guntur
Mar 20, 2004·Pediatric Pulmonology. Supplement·J C KoninckP Diot
Feb 12, 2019·ERJ Open Research·Péter Csonka, Lauri Lehtimäki
Jun 30, 2019·Pediatric Pulmonology·Péter Csonka, Lauri Lehtimäki
Apr 5, 2011·Allergy, Asthma & Immunology Research·Inseon S Choi
Jan 31, 2018·Therapeutic Advances in Respiratory Disease·Sanjeeva Dissanayake, Jason Suggett
Jan 14, 2012·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Flávia de Barros AraújoNilton Alves de Rezende
Apr 17, 2020·Molecular Pharmaceutics·Kai BerkenfeldAlf Lamprecht

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