In vitro comparison of three common essential oils mosquito repellents as inhibitors of the Ross River virus

PloS One
Miora RalambondrainyJimmy Sélambarom

Abstract

The essential oils of Cymbopogon citratus (CC), Pelargonium graveolens (PG) and Vetiveria zizanioides (VZ) are commonly used topically to prevent mosquito bites and thus the risk of infection by their vectored pathogens such as arboviruses. However, since mosquito bites are not fully prevented, the effect of these products on the level of viral infection remains unknown. To evaluate in vitro the essentials oils from Reunion Island against one archetypal arbovirus, the Ross River virus (RRV), and investigate the viral cycle step that was impaired by these oils. The essential oils were extracted by hydrodistillation and analyzed by a combination of GC-FID and GC×GC-TOF MS techniques. In vitro studies were performed on HEK293T cells to determine their cytotoxicity, their cytoprotective and virucidal capacities on RRV-T48 strain, and the level of their inhibitory effect on the viral replication and residual infectivity prior, during or following viral adsorption using the reporter virus RRV-renLuc. Each essential oil was characterized by an accurate quantification of their terpenoid content. PG yielded the least-toxic extract (CC50 > 1000 μg.mL-1). For the RRV-T48 strain, the monoterpene-rich CC and PG essential oils reduced the cy...Continue Reading

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Citations

Nov 6, 2018·BioMed Research International·Mi Young Lee
Jun 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li Ma, Lei Yao

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Datasets Mentioned

BETA
GQ433359

Methods Mentioned

BETA
transfection

Software Mentioned

GraphPad Prism
Prism
GraphPad

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