PMID: 9548601Apr 21, 1998Paper

In vitro concentration response studies and in vitro phase II tests as the experimental basis for regional chemotherapeutic protocols

Seminars in Surgical Oncology
K H LinkH G Beger

Abstract

The theoretical pharmacologic benefit of regional vs. systemic chemotherapy is defined and the concentration response behavior of cytostatic drugs and their optimal exposure times are described with human cancer cell lines (HT29, NMG64/84) and fresh human tumor cell suspensions in the human tumor colony assay (HTCA). The theoretical pharmacological advantages are 5.8 to 6 for adriamycin (ADM), 8 for cisplatinum (CDDP), 6.3 for epidoxorubicin (EPI), 22 to 58 for 5-fluorouracil (5FU), 4.6 for mitomycin C (MMC), and 6.3 for mitoxantrone (NOV). The drugs differed in their cytotoxic potency in vitro and thus also potential efficacy for regional chemotherapy; however, all but 5-fluorodeoxyuridine (5FUDR) exerted cytotoxicity dependent on exposure time and concentration. On average, elevation of the test concentrations by 1 lg doubled responses in fresh human tumor cell suspensions. From these results and clinical considerations, optimal times were defined for the regional chemotherapy strategies of hepatic artery infusion, intraperitoneal instillation, and chemoembolisation as performed at our institution.

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Citations

Jul 19, 2013·Journal of Pharmacokinetics and Pharmacodynamics·Jan LankelmaBob Kooi
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Alexander F DeVriesWerner Judmaier
Jul 16, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Meng Xu-WelliverNina A Mayr
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Jul 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Brunella BarbaroLorenzo Bonomo
Sep 28, 2014·International Journal of Radiation Oncology, Biology, Physics·Alexander Friedrich DeVriesDietmar Öfner
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Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hector BiliranJoshua D Liao

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