PMID: 1739572Jan 1, 1992

In vitro contracture tests in patients with various neuromuscular diseases

British Journal of Anaesthesia
Luc HeytensL L Bossaert


In order to investigate the relationship between neuromuscular disease and malignant hyperthermia (MH) susceptibility, the caffeine and halothane in vitro contracture test (European Malignant Hyperthermia Group Protocol) were performed in 60 patients who underwent muscle biopsy for investigation of a clinically suspected neuromuscular disorder. Two test results were classified as MH susceptible, 10 as MH equivocal and 48 MH negative. The large number of equivocal results is thought to indicate the lack of specificity of the individual components of this test in patients with clinical or histological evidence of neuromuscular disease. The increased in vitro sensitivity to the drugs tested may nevertheless provide some explanation for several in vivo "MH-like reactions" reported frequently in these patients. These reactions, however, are likely to be based on pathophysiological mechanisms different from those responsible for a true MH crisis.


Oct 1, 1996·Journal of the Neurological Sciences·K G MonsieursLuc Heytens
Sep 1, 1993·Neuromuscular Disorders : NMD·D Figarella-BrangerJ F Pellissier
May 20, 1998·Journal of the Neurological Sciences·B Yaqub, S Al Deeb
Mar 1, 2004·Journal of Clinical Neuromuscular Disease·M SnoeckGeorge Padberg
Jul 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·P J HalsallP M Hopkins
May 10, 2007·Acta Anaesthesiologica Scandinavica·M Vercauteren, Luc Heytens
Jan 11, 2008·Paediatric Anaesthesia·Jason HayesBruno Bissonnette
Oct 1, 1996·Human & Experimental Toxicology·J JouglardP J Cozzone
Sep 19, 2009·Anesthesia and Analgesia·Peter J Davis, Barbara W Brandom
Sep 19, 2009·Anesthesia and Analgesia·Harshad GurnaneyRonald S Litman
Jul 21, 2009·Anesthesia and Analgesia·John F Capacchione, Sheila M Muldoon
Jan 23, 2016·Anesthesia and Analgesia·Francis VeyckemansJean-Louis Scholtes
Jun 13, 2015·Anesthesiology·Matthew A TimminsSheila Riazi
Sep 13, 2001·European Journal of Anaesthesiology·F Wappler

Related Concepts

Disease Susceptibility
Drug Allergy
Malignant Hyperpyrexia due to Anesthesia
Foley-Denny-Brown Syndrome
Sensory Thresholds
In Vitro [Publication Type]

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