PMID: 1739572Jan 1, 1992

In vitro contracture tests in patients with various neuromuscular diseases

British Journal of Anaesthesia
Luc HeytensL L Bossaert

Abstract

In order to investigate the relationship between neuromuscular disease and malignant hyperthermia (MH) susceptibility, the caffeine and halothane in vitro contracture test (European Malignant Hyperthermia Group Protocol) were performed in 60 patients who underwent muscle biopsy for investigation of a clinically suspected neuromuscular disorder. Two test results were classified as MH susceptible, 10 as MH equivocal and 48 MH negative. The large number of equivocal results is thought to indicate the lack of specificity of the individual components of this test in patients with clinical or histological evidence of neuromuscular disease. The increased in vitro sensitivity to the drugs tested may nevertheless provide some explanation for several in vivo "MH-like reactions" reported frequently in these patients. These reactions, however, are likely to be based on pathophysiological mechanisms different from those responsible for a true MH crisis.

Citations

Oct 1, 1996·Journal of the Neurological Sciences·K G MonsieursLuc Heytens
Sep 1, 1993·Neuromuscular Disorders : NMD·D Figarella-BrangerJ F Pellissier
May 20, 1998·Journal of the Neurological Sciences·B Yaqub, S Al Deeb
Mar 1, 2004·Journal of Clinical Neuromuscular Disease·M SnoeckGeorge Padberg
Jul 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·P J HalsallP M Hopkins
May 10, 2007·Acta Anaesthesiologica Scandinavica·M Vercauteren, Luc Heytens
Jan 11, 2008·Paediatric Anaesthesia·Jason HayesBruno Bissonnette
Oct 1, 1996·Human & Experimental Toxicology·J JouglardP J Cozzone
Sep 19, 2009·Anesthesia and Analgesia·Peter J Davis, Barbara W Brandom
Sep 19, 2009·Anesthesia and Analgesia·Harshad GurnaneyRonald S Litman
Jul 21, 2009·Anesthesia and Analgesia·John F Capacchione, Sheila M Muldoon
Jan 23, 2016·Anesthesia and Analgesia·Francis VeyckemansJean-Louis Scholtes
Jun 13, 2015·Anesthesiology·Matthew A TimminsSheila Riazi
Sep 13, 2001·European Journal of Anaesthesiology·F Wappler

Related Concepts

Teens
Quick-Pep
Disease Susceptibility
Drug Allergy
Narcotan
Malignant Hyperpyrexia due to Anesthesia
Inotropism
Foley-Denny-Brown Syndrome
Sensory Thresholds
In Vitro [Publication Type]

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.