In vitro controlled release of an anti-inflammatory from daily disposable therapeutic contact lenses under physiological ocular tear flow

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Arianna TieppoMark E Byrne

Abstract

Novel molecularly imprinted, therapeutic contact lenses capable of controlled release of the non-steroidal anti-inflammatory (NSAID) diclofenac sodium were synthesized, exploiting ionic non-covalent interactions. Poly(HEMA-co-DEAEM-co-PEG200DMA) soft contact lenses were prepared (105±5 μm thickness, diameter 15.0±0.2mm, base curve of 8.6±0.2mm) with different monomer to template ratios and dynamic release studies were conducted in artificial lacrimal solution using two different in vitro methods. Under infinite sink conditions, imprinted contact lenses demonstrated concentration dependent release kinetics. Under physiological flow rates, by increasing the M/T ratio from 1 to 10.5, the release rate decreased from 11.72 μg/h to 6.75 μg/h during the first 48 h. The release rate was more constant, moving toward zero-order release. To use these lenses as daily disposable lenses, the first 24h of release was studied and found to be linear with a rate of 17.27, 11.99, and 8.74 μg/h for M/T ratios of 1, 3.5, and 10.5, respectively. Furthermore, the lenses prepared with a M/T ratio of 10.5 released diclofenac at a rate close to the maximum dose delivered by commercial eye drops, making them ideal for use as daily disposable lenses, and ...Continue Reading

References

Sep 1, 1990·Journal of Medicinal Chemistry·P MoserI Wiesenberg
Aug 1, 1990·The British Journal of Ophthalmology·A J WinfieldL Esakowitz
Apr 28, 1986·The American Journal of Medicine·A R Sallmann
Feb 1, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·R D SchoenwaldC F Barfknecht
Jan 10, 2003·Journal of Biomaterials Science. Polymer Edition·Bumsang Kim, Nicholas A Peppas
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rei UchidaKenji Uno
Feb 26, 2004·Journal of the American Chemical Society·Ramesh SrinivasanAhmed H Zewail
Feb 24, 2005·International Journal of Pharmaceutics·Derya Gulsen, Anuj Chauhan
Aug 6, 2005·Macromolecular Bioscience·Haruyuki HirataniCarmen Alvarez-Lorenzo
Dec 16, 2005·Current Eye Research·Derya GulsenAnuj Chauhan
Mar 2, 2006·Expert Opinion on Drug Delivery·Deepta Ghate, Henry F Edelhauser
Jul 14, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lynn C WintertonL Lawrence Chapoy
Jul 18, 2006·Eye & Contact Lens·Masumi KanemotoAkira Murakami
Sep 30, 2006·Biomaterials·Siddarth VenkateshMark E Byrne
Nov 3, 2006·Journal of Pharmaceutical Sciences·Paula Andrade-ViveroAngel Concheiro
Feb 1, 2007·Journal of Biomedical Materials Research. Part a·Anne DanionPatrick Vermette
Oct 27, 2007·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Li XinmingLiao Liewen
Oct 30, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maryam AliMark E Byrne
May 27, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Siddarth VenkateshMark E Byrne
Dec 10, 2008·Biomaterials·Jose-Fernando Rosa dos SantosAngel Concheiro
May 3, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mara E M BragaHermínio C de Sousa
Jan 1, 2008·Expert Review of Clinical Pharmacology·Maryam Ali, Mark Edward Byrne

❮ Previous
Next ❯

Citations

Dec 12, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ana Guzman-AranguezJesús Pintor
Sep 13, 2013·Therapeutic Delivery·Clara González-ChomónCarmen Alvarez-Lorenzo
Jun 5, 2014·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Arianna TieppoMark E Byrne
May 6, 2015·Journal of Functional Biomaterials·Shyam S ChaurasiaRajiv R Mohan
Jul 24, 2013·Expert Opinion on Drug Delivery·Lokendrakumar C BenganiAnuj Chauhan
Jan 30, 2016·Drug Delivery·Furqan A MaulviDinesh O Shah
Nov 3, 2012·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·P Cho, M V Boost
Aug 25, 2015·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Anisa MahomedBrian J Tighe
Mar 19, 2014·The Journal of Pharmacy and Pharmacology·Joel G SouzaRenata F V Lopez
Feb 17, 2015·Future Medicinal Chemistry·Mariacristina Gagliardi, Barbara Mazzolai
May 26, 2016·Acta Biomaterialia·Clara González-ChomónCarmen Alvarez-Lorenzo
Jun 21, 2016·Current Opinion in Biotechnology·Stephen A DiPasquale, Mark E Byrne
Nov 3, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nathan Efron
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Piotr Luliński
Jan 11, 2017·Scientific Reports·Mariacristina GagliardiAngelo Bifone
Apr 21, 2017·Drug Development and Industrial Pharmacy·Silvia PescinaSara Nicoli
Sep 26, 2017·Eye & Contact Lens·Siwei ZhouRobert M Q Shanks
Mar 23, 2019·Nanomedicine·Aseel Mahmood Ibrahim Al-MashahedahJagat Rakesh Kanwar
Aug 23, 2019·Biomaterials Science·Young Ju SonHyuk Sang Yoo
Jan 7, 2020·Journal of Biomaterials Science. Polymer Edition·Xiuju ZhangPing Qi
Dec 8, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Chau-Minh PhanLyndon W Jones
Sep 16, 2015·Eye & Contact Lens·Ana Guzman-AranguezJesús Pintor
Apr 19, 2015·Journal of Biomaterials Applications·Myrto KorogiannakiHeather Sheardown
Sep 20, 2019·Translational Vision Science & Technology·Chau-Min PhanLyndo Jones
Feb 22, 2014·Journal of Biomaterials Applications·Giuliano GuidiHeather Sheardown
Jan 15, 2020·AAPS PharmSciTech·Feng YanNannan Liu
Jul 1, 2020·Expert Opinion on Drug Delivery·Olivia L LanierAnuj Chauhan
Mar 24, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Lyndon W JonesLakshman Subbaraman
Sep 25, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alex Hui
Mar 7, 2021·Pharmaceutics·Chau-Minh PhanLyndon Jones
Aug 28, 2020·Acta Biomaterialia·Xin FanAllan E David
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Lyndon JonesMark Willcox
May 30, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Olivia L LanierAnuj Chauhan
Jun 15, 2021·Journal of Drug Delivery Science and Technology·Liana D WuchteMark E Byrne
Aug 7, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Dan Chau Thuy NguyenLaurence Fitzhenry
Sep 15, 2021·Advanced Healthcare Materials·Stephen A DiPasqualeMark E Byrne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Arianna TieppoMark E Byrne
Journal of Controlled Release : Official Journal of the Controlled Release Society
Maryam AliMark E Byrne
Drug Discovery Today
Himanshu Gupta, Mohammed Aqil
© 2022 Meta ULC. All rights reserved