In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine, and MIV-150, Nonnucleoside Reverse Transcriptase Inhibitor Microbicides in Clinical Development for the Prevention of HIV-1 Infection

Antimicrobial Agents and Chemotherapy
Nicholas S Giacobbi, Nicolas Sluis-Cremer

Abstract

Rilpivirine (RPV), dapivirine (DPV), and MIV-150 are in development as microbicides. It is not known whether they will block infection of circulating nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant human immunodeficiency virus type 1 (HIV-1) variants. Here, we demonstrate that the activity of DPV and MIV-150 is compromised by many resistant viruses containing single or double substitutions. High DPV genital tract concentrations from DPV ring use may block replication of resistant viruses. However, MIV-150 genital tract concentrations may be insufficient to inhibit many resistant viruses, including those harboring K103N or Y181C.

References

Feb 18, 2010·Antimicrobial Agents and Chemotherapy·Gerben van 't KloosterLieven Baert
Nov 30, 2011·Antimicrobial Agents and Chemotherapy·Susan M SchaderMark A Wainberg
May 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jessica H BrehmUNKNOWN CIPRA-SA Project 1 Study Team
Oct 9, 2013·Current Opinion in HIV and AIDS·William R SpreenJohn C Pottage
Jun 3, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Beatrice A ChenCharlene S Dezzutti
Feb 7, 2016·The Journal of Antimicrobial Chemotherapy·Kevin K AriënGuido Vanham
Feb 24, 2016·The New England Journal of Medicine·Jared M BaetenUNKNOWN MTN-020–ASPIRE Study Team
Jul 21, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Barbara A FriedlandGeorge W Creasy
Dec 14, 2016·The New England Journal of Medicine·Annalene NelUNKNOWN Ring Study Team

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Citations

Mar 30, 2018·Expert Review of Clinical Pharmacology·Laura Benítez-GutiérrezCarmen de Mendoza
Mar 17, 2021·Antimicrobial Agents and Chemotherapy·Yuliang Wei, Nicolas Sluis-Cremer

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