PMID: 4294106Nov 1, 1967Paper

In vitro cultivation and immunofluorescent studies of transplantable carcinomas Vx2 and Vx7. Persistence of a Shope virus-related antigenic substance in the cells of both tumors

The Journal of Experimental Medicine
T Osato, Y Ito

Abstract

The Vx2 and Vx7 rabbit carcinomas, both of Shope papilloma derivation, were cultivated in vitro and studied for immunofluorescence indicative of the presence of viral antigen. The cultured Vx7 cells were characteristically pleomorphic, round or polygonal cells, and immunofluorescence was demonstrable in 5-20% of them as counted on cover slip cultures after exposure to rabbit sera containing anti-Shope papilloma virus antibody. The Vx2 cells in contrast to this were of almost uniform size and character, small and approximately round, and the specific fluorescence was found in less than 0.1% of the total number. These findings indicate that some antigenic derivation from the Shope papilloma virus is still persisting at least in some fractions of the cells, not only of Vx7 tumors but also of the Vx2 tumors, even after maintenance of the growths by transplantation for more than 20 yr. During the course of the study, two lines of the Vx7 were kept continually growing while the culture of Vx2 was discontinued at its tenth passage after an accident due to mechanical failure of the incubator. The neoplastic capacity of the Vx7 cells cultured in vitro was demonstrated by implanting these intradermally on the ears of domestic rabbits. Th...Continue Reading

References

Jun 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·O ShiratoriY Ito

❮ Previous
Next ❯

Citations

Jan 1, 1982·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D M Easty, G C Easty
Apr 6, 2012·The Journal of Surgical Research·John A HandalSolomon P Samuel
Jun 1, 1982·Microbiological Reviews·W D Lancaster, C Olson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
D ProschekA A Kurth
Virchows Archiv. B, Cell Pathology Including Molecular Pathology
D M Easty, G C Easty
The Journal of Surgical Research
John A HandalSolomon P Samuel
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
S A Shah, J A Dickson
Journal of Magnetic Resonance Imaging : JMRI
Jiqing SongRoberto Blanco Sequeiros
© 2021 Meta ULC. All rights reserved