In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei from sporozoites

Science
M R HollingdaleR L Beaudoin

Abstract

When inoculated with sporozoites of Plasmodium berghei, the human embryonic lung cell line WI38 supports the complete asexual developmental cycle of the exoerythrocytic stage. Cultured parasites were sensitive to primaquine, were shown to resemble parasites in living hosts by immunofluorescent antibody tests, and on subinoculation into mice induced a red blood cell infection, the gametocytes of which produced sporozoites in anopheline mosquitoes.

References

Dec 1, 1979·Microbiological Reviews·I W Sherman
Sep 1, 1973·The American Journal of the Medical Sciences·D F ClydeJ P Vanderberg

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Citations

Jan 1, 1982·Zeitschrift Für Parasitenkunde·J F MeisJ H Meuwissen
Oct 15, 1988·Experientia·J Eckert
Sep 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·G W LongS L Hoffman
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·P Pirson
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·M R Hollingdale, P Leland
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·P LelandM R Hollingdale
Oct 31, 2009·Nature Reviews. Drug Discovery·Dominique MazierGeorges Snounou
Oct 17, 2006·Nature Reviews. Microbiology·Miguel PrudêncioMaria M Mota
Apr 21, 1983·The New England Journal of Medicine·D J Wyler
Jul 1, 1994·The Journal of Experimental Medicine·P SinnisV Nussenzweig
Mar 1, 1992·The Journal of protozoology· SyafruddinF Kawamoto
Jul 5, 2002·Clinical Microbiology Reviews·Frederick L Schuster
Oct 4, 2011·PLoS Pathogens·Emily R DerbyshireJon Clardy
Jan 19, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Thabang Mokgethi-Morule, David D N'Da
Dec 1, 1987·Experimental Parasitology·D MazierM Gentilini
Mar 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M R Hollingdale
Nov 23, 2006·International Journal for Parasitology·Olivier SilvieDominique Mazier
Apr 13, 2011·PloS One·Laurent DembeleDominique Mazier
Apr 3, 2014·Parasitology International·Satoko ItaniTomoko Ishino
Jun 26, 2012·International Journal for Parasitology·Michelle N Wykes, Joshua Horne-Debets
Mar 25, 2015·Cell Host & Microbe·Sebastian A MikolajczakStefan H I Kappe
Apr 1, 2017·Scientific Reports·Shengyong NgSangeeta N Bhatia
Sep 17, 2013·Nature Reviews. Microbiology·Robert MénardRogerio Amino
Nov 13, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L H MillerT J Hadley

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