PMID: 6966335Apr 1, 1980Paper

In vitro cytotoxicity against Marek's disease lymphoblastoid cell lines after enzymatic removal of Marek's disease tumor-associated surface antigen

Journal of Virology
K A Schat, K K Murthy

Abstract

Marek's disease tumor-associated surface antigen (MATSA) has been claimed to be the target of cytotoxic lymphocytes in in vitro tests for Marek's disease immunity. Treatment with papain, but not with trypsin or mixed glycosidases, removed MATSA from certain Marek's disease lymphoblastoid cell lines. Tumor cells with and without MATSA were used as target cells for in vitro studies on cell-mediated immune responses with sensitized spleen cells in a chromium release assay. The removal of MATSA did not influence the results of the chromium release assay. Attempts to block the cell-mediated cytotoxicity in vitro by coating tumor cells with an anti-MATSA serum failed. It was concluded that cell-mediated immune responses against Marek's disease tumor cells are directed against an as yet undefined antigen(s).

References

May 1, 1978·Journal of the National Cancer Institute·K A Schat, B W Calnek
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Citations

Jan 1, 1986·Critical Reviews in Microbiology·B W Calnek
Apr 1, 1983·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·K OzakiT Mikami
Jan 1, 1981·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·K SuzukiH Izawa
Jan 1, 1987·Avian Pathology : Journal of the W.V.P.A·E D Heller, K A Schat
Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·K A SchatH Abplanalp
Jul 1, 1984·Avian Pathology : Journal of the W.V.P.A·K A Schat, W R Shek
Feb 1, 1989·European Journal of Immunology·D WeinstockB W Calnek
Jan 1, 1986·Avian Pathology : Journal of the W.V.P.A·K A SchatD Weinstock
Apr 1, 1994·Veterinary Immunology and Immunopathology·S DandapatG C Mohanty

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