In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark

BioMed Research International
Stephane ZingueDieudonné Njamen

Abstract

The present study was designed to evaluate the in vitro and in vivo antitumor effects of A. seyal hydroethanolic extract on breast cancer. The cytotoxicity of A. seyal extract was evaluated using resazurin reduction assay in 9 cell lines. Further, the protective effect of the hydroethanolic extract of A. seyal stem barks was evaluated on 7,12-dimethylbenz(a)anthracene- (DMBA-) induced breast cancer rat model. Incidence, burden, volume, and histological analysis of mammary tumors were measured. The Acacia seyal extract exhibited CC50 of 100 in MCF-7 cells after 24 h. In vivo, no tumors were detected in rats from the control group, while 11 rats out of 12 (91.66%) developed mammary tumors in the DMBA-exposed group receiving only the vehicle. Acacia seyal extract significantly (p < 0.01) and in the dose-dependent manner reduced tumor incidence (3 rats out of 12 at the dose of 300 mg/kg), burden [62.1% (150 mg/kg) and 65.8% (300 mg/kg)], and mass. It protected rats against DMBA-induced breast hyperplasia, with an optimal effect at the dose of 300 mg/kg. Taken altogether, these results suggest that the hydroethanolic extract of Acacia seyal might contain phytoconstituents endowed with antitumoral properties, which could protect agai...Continue Reading

References

Jan 1, 1982·Breast Cancer Research and Treatment·J RussoI H Russo
Mar 15, 1983·International Journal of Cancer. Journal International Du Cancer·D K SinhaT L Dao
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Jan 20, 2006·The New England Journal of Medicine·James D Yager, Nancy E Davidson
Feb 3, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sarah E LillieBarbara K Rimer
May 10, 2008·Cancer Letters·Akira MurakamiJunji Terao
Oct 8, 2008·Annals of the New York Academy of Sciences·Wafa S Al-DhaheriSherif M Karam
Feb 3, 2009·Environmental Research·Sharon K SagivMarilie D Gammon
Mar 29, 2011·The Lancet Oncology·Jack CuzickHeinz Zwierzina
Apr 16, 2011·Phytotherapy Research : PTR·Tayyab A MansoorMaria-José U Ferreira
Jul 28, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Lara GibelliniAndrea Cossarizza
May 16, 2012·Anti-cancer Agents in Medicinal Chemistry·Aditi S VadodkarChendil Damodaran
May 16, 2012·Anti-cancer Agents in Medicinal Chemistry·Hu WangAh-Ng Tony Kong
Feb 14, 2013·International Journal of Cancer. Journal International Du Cancer·Anupam BishayeeDeepak Bhatia
Jun 6, 2013·British Journal of Cancer·W P Steward, K Brown
Aug 7, 2013·Hematology/oncology Clinics of North America·Matteo Lazzeroni, Andrea DeCensi
Oct 25, 2013·International Journal of Molecular Sciences·Sibaji SarkarMcKenna Longacre
Jan 24, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Anupam Bishayee, Animesh Mandal
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Oct 5, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marlowe S Tessmer, Kenneth C Anderson
May 27, 2017·International Journal of Molecular Sciences·Kevine Kamga SiliheTânia Beatriz Creczynski-Pasa

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

GraphPad Prism
Axio Vision

Related Concepts