In vitro Cytotoxicity Effects of (197)Au/PAMAMG4 and (198)Au/PAMAMG4 Nanocomposites Against MCF7 and 4T1 Breast Cancer Cell Lines

Advanced Pharmaceutical Bulletin
Simin Janitabar-DarziKamal Yavari

Abstract

Purpose: Study on gold based therapeutic agents for cancer cells deracination has become under scrutiny in recent years owing to effective treatments are not available for rapidly progressive cancers. The aim of present study was to examine efficiency of radioactive (198)Au/PAMAMG4 and non-radioactive (197)Au/PAMAMG4 nancomposites against 4T1 and MCF7 breast cancer cell lines. Methods: The PAMAMG4 dendrimer was treated with the gold anions and then, the mixture was chemically reduced by NaBH4. Prepared (197)Au/PAMAMG4 was bombarded by thermal neutrons in the Tehran Research Reactor to (198)Au/PAMAMG4 be produced. Prepared nanocomposites were characterized by means of FT-IR, 1H NMR, Zeta-potential measurements, TEM and EDX analyses. The radionuclidic purity of the (198)Au/PAMAMG4 solution was determined using purity germanium (HPGe) spectroscopy and its stability in the presence of human serum was studied. In vitro studies were carried out to compare toxicity of PAMAMG4, (197)Au/PAMAMG4 and (198)Au/PAMAMG4 towards 4T1 and MCF7 cancerous cells and C2C12 normal cell lines. Results: Characterization results exhibited that invitro agents, (197)Au/PAMAMG4 and (198)Au/PAMAMG4, were synthesized successfully. Cells viability after 24 h,...Continue Reading

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Citations

Dec 13, 2019·Macromolecular Bioscience·Tingting XiaoMingwu Shen
May 5, 2018·Advanced Healthcare Materials·Myriam Laprise-PelletierMarc-André Fortin
Feb 23, 2020·Anti-cancer Agents in Medicinal Chemistry·Reza RezaeiMahnaz Yazdani
Mar 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Serge MignaniJean-Pierre Majoral

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Methods Mentioned

BETA
NMR
nuclear magnetic resonance
transmission
X-ray
ELISA

Software Mentioned

SPSS Statistic

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