In vitro cytotoxicity of a low-shrinkage polymerizable liquid crystal resin monomer

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Edward J BolandBarry K Norling

Abstract

The objective of this study was to determine the in vitro cytotoxicity of novel, polymerizable liquid crystal resin monomers when placed in direct contact with dental and nondental cell lines. One common dimethacrylate and three liquid crystal compounds, Bis-glycidyl methacrylate (Bis-GMA), 2-(t-butyl)-1,4-bis-{4-(6-acryloxy-hexane-1-oxy)-benzoyloxy}-benzene (C6), 2-(t-butyl), 1-[6-(3-acryloxy-propionoxy)-hexane-1-oxy-benzoyloxy], 4-[4-(6-acryloxy-hexane-1-oxy)-benzoyloxy]-benxene (by-product), and a 3:2 mixture of C6 and by-product, respectively, were tested for relative cytotoxicity in vitro. Cultured dental and nondental cells were treated for 24 h with test compound dissolved in media over a fourfold range of concentration (10(-4) -10(-7) mol/L). Cytotoxicity was measured using the WST-1 reagent as an indicator of remaining cell numbers based on the reduction of WST-1 substrate by mitochondrial dehydrogenases in viable cells. Bis-GMA ID(50) was found to be consistent with ID(50) values reported in the literature. A small but significant difference in the sensitivity of the dental and nondental cells in regard to their response to this dimethacrylate was noted. The liquid crystal resin monomers were significantly less cytoto...Continue Reading

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Citations

Oct 12, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Yasaman DelavizJ Paul Santerre
Jun 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sharon GerechtGordana Vunjak-Novakovic
Jan 18, 2014·Journal of Materials Science. Materials in Medicine·Tinca BuruianaEmil C Buruiana
Sep 27, 2016·Journal of Oral Science·Reyhan ŞişmanErdal Karaöz

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