In vitro cytotoxicity of maxillofacial silicone elastomers: effect of accelerated aging

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Bilge Turhan BalSükran Yilmaz

Abstract

The purpose of this in vitro study was to evaluate the cytotoxicity of three maxillofacial silicone elastomers at 24, 48, and 72 h on L-929 cells and to determine the effect of accelerated aging on the cytotoxicity of these silicone elastomers. Disc-shaped test samples of maxillofacial silicone elastomers (Cosmesil, Episil, Multisil) were fabricated according to manufacturers' instructions under aseptic conditions. Samples were then divided into three groups: (1) not aged; (2) aged for 150 h with an accelerated weathering tester; and (3) aged for 300 h. Then the samples were placed in Dulbecco's Modified Eagle Medium/Ham's F12 (DMEM/F12) for 24, 48, and 72 h. After the incubation periods, cytotoxicity of the extracts to cultured fibroblasts (L-929) was measured by MTT assay. The degree of cytotoxicity of each sample was determined according to the reference value represented by the cells with a control (culture without sample). Statistical significance was determined by repeated measurement ANOVA (p < 0.01) followed by Duncan's test (p < 0.05). All test materials in each group demonstrated high survival rates in MTT assay (Episil; 93.84%, Multisil; 88.30%, Cosmesil; 87.50%, respectively); however, in all groups, Episil material...Continue Reading

References

Jan 1, 1978·Journal of Biomedical Materials Research·R M RiceR K Kulkarni
Oct 1, 1992·The Journal of Prosthetic Dentistry·S P HaugM Okamura
Aug 1, 1992·The Journal of Prosthetic Dentistry·C J AndresG Bernal
Aug 1, 1992·The Journal of Prosthetic Dentistry·J F WolfaardtG Ackermann
Jan 1, 1992·Dental Materials : Official Publication of the Academy of Dental Materials·J C WatahaC T Hanks
Nov 1, 1991·Journal of Dental Research·C T HanksR G Craig
Mar 1, 1988·International Endodontic Journal·A Hensten-Pettersen
Apr 1, 1980·The Journal of Prosthetic Dentistry·D H Lewis, D J Castleberry
Jan 1, 1980·Acta Odontologica Scandinavica·A Hensten-Pettersen, A Hulterström
Apr 1, 1980·Biomaterials·R G CraigR Yu
Sep 1, 1995·The Journal of Prosthetic Dentistry·W C WagnerA Koran
Feb 1, 1994·The Journal of Prosthetic Dentistry·C A Lefebvre, G S Schuster
May 1, 1994·The Journal of Prosthetic Dentistry·G L PolyzoisA Kullmann
May 1, 1994·The Journal of Prosthetic Dentistry·G L PolyzoisA Kullman
Sep 1, 1995·Dental Materials : Official Publication of the Academy of Dental Materials·T A BeanD M Yourtee
May 1, 1996·Dental Materials : Official Publication of the Academy of Dental Materials·C T HanksZ Sun
Apr 29, 1998·Clinical Oral Investigations·G Schmalz
Mar 30, 1999·The Journal of Prosthetic Dentistry·M G WatersG L Polyzois
Aug 29, 2000·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·E C RoseH F Kappert
Oct 18, 2000·Journal of Immunological Methods·P Upadhyay, S Bhaskar
May 18, 2001·The Journal of Prosthetic Dentistry·S Kiat-AmnuayL J Goldsmith
Aug 22, 2001·The Journal of Prosthetic Dentistry·J C Wataha
May 7, 2002·Dental Materials : Official Publication of the Academy of Dental Materials·B ThonemannH Schweikl
Jul 30, 2003·The Journal of Prosthetic Dentistry·Janaina Habib JorgeCarlos Eduardo Vergani
Jun 26, 2007·Dental Clinics of North America·Kenneth R St John

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Citations

Apr 29, 2009·Journal of Materials Science. Materials in Medicine·Bilge Turhan BalBenay Tokman
May 7, 2011·Journal of Biomedical Materials Research. Part a·Dorota KowalczukAgata Przekora
Jul 17, 2016·The Journal of Prosthetic Dentistry·Emily Vivianne Freitas da SilvaSandra Helena Penha de Oliveira
Nov 12, 2016·The Journal of Prosthetic Dentistry·Liliane da Rocha BonattoDaniela Micheline Dos Santos
Sep 7, 2016·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Canan AkayHandan Sevim
Jul 11, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Emily Vivianne Freitas da SilvaDaniela Micheline Dos Santos

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