In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
Karina F DevienneWagner Vilegas

Abstract

Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy-1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromelioides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic.

Citations

Nov 25, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E A VarandaW Vilegas
Jun 17, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·K Ferrazzoli DevienneW Vilegas
Dec 23, 2014·Natural Product Reports·Christopher D Donner
Jul 14, 2004·Natural Product Research·Haba HamadaCatherine Lavaud
Jan 17, 2014·Biological & Pharmaceutical Bulletin·Rita de Cássia Ribeiro GonçalvesSandra Regina Pombeiro-Sponchiado
Nov 23, 2017·Rapid Communications in Mass Spectrometry : RCM·Ana C ZanattaLourdes Campaner Dos Santos
Jun 17, 2003·Biological & Pharmaceutical Bulletin·Rodrigo Rezende KitagawaLuiz Marcos da Fonseca
Nov 8, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Eliana Aparecida VarandaLourdes Campaner Dos Santos

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