In vitro degradation of the flavonol quercetin and of quercetin glycosides in the porcine hindgut

Archives of Animal Nutrition
Rainer Cermak, GerhardBrLüpke MatthiaseWolffram Siegrfried Breves

Abstract

The present study investigated the microbial degradation of the plant flavonol quercetin and its naturally occurring glycosides isoquercitrin and rutin in the porcine hindgut. The experiments were carried out with the semicontinuous colon-simulation technique. The fluid and particle phase of pig hindgut contents from freshly slaughtered animals were used for the in vitro incubations. Following a five-day equilibration period, quercetin, isoquercitrin or rutin were administered to fermentation vessels and their turnover rate was determined. None of the flavonols affected parameters of microbial fermentation like pH, redox potential or VFA production. The turnover rate for isoquercitrin was seven times higher than the turnover for the fermentation fluid. The turnover rates for quercetin and rutin were four and twofold higher than fluid turnover, respectively. After administration of isoquercitrin or rutin, their aglycone quercetin was detected as an intermediary metabolite. Under sterile conditions using autoclaved incubation fluids and hindgut contents, turnover rates for quercetin and rutin were still higher than the fluid turnover in the fermentation vessels. This indicates a certain chemical instability of the flavonols and/o...Continue Reading

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Citations

Mar 17, 2010·The British Journal of Nutrition·Marianne ReinbothRainer Cermak
Apr 26, 2007·Critical Reviews in Food Science and Nutrition·K Nemeth, M K Piskula
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·John van DuynhovenTom Van de Wiele
May 16, 2014·Nutrition Reviews·Torsten Bohn
Mar 29, 2008·Expert Opinion on Drug Metabolism & Toxicology·Rainer Cermak
Apr 1, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kateřina ValentováVladimír Křen
Jun 22, 2015·Journal of Dairy Science·L M BergerS Wolffram
May 1, 2018·Comprehensive Reviews in Food Science and Food Safety·A Filipa AlmeidaCláudia N Santos
Sep 14, 2021·Critical Reviews in Food Science and Nutrition·Qiqiong Li, Tom Van de Wiele
Jan 29, 2021·Protein and Peptide Letters·Aline M Hilzendeger Zilli, Eduardo M Zilli

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