PMID: 7018860Jan 1, 1981Paper

In vitro determinants of plasma renin activity in serially-studied inbred dogs with neonatally induced coarctation hypertension: renin reactivity, renin substrate, and renin concentration

Clinical and Experimental Hypertension : CHE
S P BagbyD K Gray

Abstract

Increased renin activity of plasma, suggesting an excess of circulating accelerators and/or deficit of inhibitors of the renin reaction, has been reported in a number of hypertensive states; however, its contribution to genesis and/or maintenance of hypertension is unknown. To longitudinally assess the evolution of plasma renin reactivity in relation to blood pressure in neonatally-induced coarctation hypertension, we have made serial observations in 6 coarcted dogs and in 7 littermate controls over 1-12 months post-aortic-banding during varied steady-state sodium intake. Measurements of renin activity (defined as the increment of angiotensin I-generation rate following addition of exogenous renin to plasma), renin substrate concentration (RS), and plasma renin activity (PRA), together with calculation of plasma renin concentration (PRC) (as PRC = PRA divided by renin reactivity) provided estimates of the three major determinants of PRA. RS values were adjusted for variability due to assay-control and to age via covariate analysis. Results indicate no difference in adjusted RS between coarcted and control dogs, thus obviating the influence of RS differences on renin reactivity results. Renin reactivity and PRC in coarcted dogs ...Continue Reading

References

Mar 1, 1979·Hypertension·R E DruilhetW M Kirkendall
Jun 1, 1975·Circulation Research·M P SambhiC Thananopavarn
Jul 1, 1977·The American Journal of the Medical Sciences·M CraigR B Hickler
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·W J McDonaldJ W Conn
May 1, 1971·European Journal of Clinical Investigation·E Rosset, R Veyrat
Jan 1, 1972·The Journal of Clinical Investigation·M P Sambhi, C E Wiedeman
Jun 1, 1972·The Journal of Clinical Endocrinology and Metabolism·T A KotchenD R Walters
Apr 1, 1972·Kidney International·J E SealeyJ H Laragh
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·D B Gordon, I N Sachin

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Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·J ElmgreenN J Christensen
Apr 1, 1994·British Journal of Clinical Pharmacology·N V OlsenP P Leyssac
Mar 27, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·T GotoK Murakami
Feb 5, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yanling ZhangTingting Chen

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