In vitro development of primitive and definitive erythrocytes from different precursors

Science
T NakanoT Honjo

Abstract

During mouse embryogenesis the production of "primitive" erythrocytes (EryP) precedes the production of "definitive" erythrocytes (EryD) in parallel with the transition of the hematopoietic site from the yolk sac to the fetal liver. On a macrophage colony-stimulating factor-deficient stromal cell line OP9, mouse embryonic stem cells were shown to give rise to EryP and EryD sequentially with a time course similar to that seen in murine ontogeny. Studies of the different growth factor requirements and limiting dilution analysis of precursor frequencies indicate that most EryP and EryD probably developed from different precursors by way of distinct differentiation pathways.

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Citations

Jul 13, 2002·The Journal of Pathology·Anne E BishopJulia M Polak
May 25, 2001·International Journal of Hematology·A Suzuki, T Nakano
Jun 6, 2008·In Vitro Cellular & Developmental Biology. Animal·Hai-Jun HuangSi-Wen Jiang
Mar 13, 2010·International Journal of Hematology·Michinori Kitagawa, Takumi Era
Dec 25, 2010·International Journal of Hematology·Yukio NakamuraRyo Kurita
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Nov 5, 2003·Trends in Immunology·Toru Nakano
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