In Vitro Differentiation of Effector CD4+ T Helper Cell Subsets

Methods in Molecular Biology
Kaitlin A ReadKenneth J Oestreich

Abstract

CD4+ T "helper" cells are key orchestrators of adaptive immune responses. Upon activation, naïve CD4+ T cells are capable of differentiating into a number of effector subsets that perform distinct immune functions. These subsets include T helper 1 (TH1), TH2, TH9, TH17, TH22, T follicular helper (TFH), and regulatory T cell (TREG) populations. The differentiation of these subsets is dependent, in large part, on the coordinated interplay between signals from the extracellular cytokine environment and downstream transcriptional networks. The use of in vitro T helper cell culture systems has been extensively employed to aid in the elucidation of the molecular mechanisms that govern the differentiation of each effector subset. Here, we provide a detailed summary of the differentiation conditions that are utilized to generate effector CD4+ T cell populations in vitro.

Citations

Nov 23, 2019·Cellular & Molecular Immunology·Xin GaoDi Yu
Sep 3, 2021·Gastroenterology Research and Practice·Lulu SunDashan Wang
Aug 25, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Waseem LoneJaveed Iqbal
Nov 25, 2019··选明 杨民 李

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