In vitro effect of acrylonitrile on specific activities of human polymorphonuclear leucocytes

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M GovernaM Amati

Abstract

N-Formyl-methionyl-leucyl-phenylalanine (F-MLP)-induced chemotaxis and luminolamplified chemiluminescence were studied in isolated human polymorphonuclear leucocytes (PMN) and exposed to acrylonitrile (ACN) in vitro. Chemotaxis was reduced at ACN concentrations of 3 mm and above, while respiratory burst was affected at ACN concentrations of 18mm and above. The ACN concentrations were highly correlated both with decreased chemotactic activity (r = 0.75; P < 0.05) and with decreased respiratory burst (r = 0.93; P < 0.01).

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May 19, 2000·British Journal of Cancer·D Valik, M Nekulova

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