In vitro effect of advanced glycation end-products on human polymorphonuclear superoxide production

European Journal of Clinical Investigation
J BernheimB Wolach

Abstract

Advanced glycation end-products (AGEs) are elevated in the sera of diabetic patients. The latter are prone to severe bacterial infections. Advanced glycation end-products have been shown to modulate immune competent cell activities. In this study we examined the in vitro effect of advanced glycation end-products on superoxide anion generation by human polymorphonuclear leukocytes. Advanced glycation end-products were prepared by incubation of bovine serum albumin (BSA) with glucose for 90 days. Superoxide production was measured as the superoxide dismutase-inhibitable reduction of ferricytochrome c. The effect of advanced glycation end-products on superoxide production was evaluated in both baseline (nonstimulated) and stimulated (by either formyl-methionyl-leucyl-phenylalanine, or phorbol-myristate-acetate) polymorphonuclear leukocytes. The baseline superoxide production of polymorphonuclear leukocytes was significantly increased by advanced glycation end-products in a dose-dependent manner. In contrast, in stimulated polymorphonuclear leukocytes advanced glycation end-products significantly inhibited superoxide production, again in a dose-dependent manner. This inhibitory effect of advanced glycation end-products was observed...Continue Reading

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Citations

Mar 21, 2002·European Journal of Clinical Investigation·G GlorieuxN Lameire
Oct 22, 2004·Kidney International·Griet GlorieuxRaymond Vanholder
Mar 30, 2004·Artificial Organs·Tony Bouré, Raymond Vanholder
Mar 16, 2011·European Journal of Internal Medicine·Stephanie SeneffLuca Mascitelli
Feb 23, 2008·Molecular Nutrition & Food Research·Tomoko Oya-ItoNorio Ohashi
Dec 20, 2005·Blood Purification·R VanholderN Lameire
Apr 10, 2019·Neural Regeneration Research·Dhanushka GunawardenaGerald Münch
Feb 24, 2011·Biomedit︠s︡inskai︠a︡ khimii︠a︡·N A Ansari, Z Rasheed

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