PMID: 15227798Jul 2, 2004Paper

In vitro effect of C2-C18 fatty acids on Salmonellas

Folia Microbiologica
Eva SkrivanováMilan Marounek

Abstract

The susceptibility of Salmonella spp. to 15 fatty acids was determined in vitro in cultures grown on glucose. Antimicrobial activity was expressed as IC50 (a concentration at which only 50% of the initial glucose in cultures was utilized). Caprylic acid was the only acid inhibiting glucose utilization. In cultures of S. enteritidis, S. infantis and S. typhimurium, IC50 of caprylic acid ranged from 0.75 to 1.17 mg/mL. A moderate adaptation effect was observed as these values increased 1.5-1.8 times when bacteria were subcultured 10 times in media containing a low concentration of caprylic acid (1/3 IC50). No effect of calcium ions added in excess on antimicrobial activity of caprylic acid was observed. Incubation of salmonellas with caprylic acid (1 mg/mL; 30 min) at pH 5.2-5.3 led to a reduction in the concentration of viable cells below the detection limit; 2-6% of Salmonella cells survived at pH 6.3-6.6.

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Citations

Sep 29, 2006·Folia Microbiologica·M MarcinákováA Lauková
Nov 20, 2014·Foodborne Pathogens and Disease·Eva SkřivanováMilan Marounek
Sep 14, 2012·The Quarterly Review of Biology·Joe AlcockChristopher W Kuzawa
Sep 25, 2015·Applied Microbiology and Biotechnology·Jelena RadivojevicKevin E O'Connor
Jun 18, 2005·Letters in Applied Microbiology·E SkrivanováJ Kanka
Apr 21, 2020·Journal of Food Protection·Janak Dhakal, Charles G Aldrich
Apr 13, 2018·International Journal of Molecular Sciences·Bo Kyeong YoonNam-Joon Cho

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