In vitro effect of genistein on DNA damage in leukocytes from mucopolysaccharidosis IVA patients

Molecular Genetics and Metabolism
G W NegrettoCarmen R Vargas

Abstract

Mucopolysaccharidosis IVA is a lysosomal storage disorder leading to an increase in glycosaminoglycans storage. Genistein is an isoflavone capable to inhibit glycosaminoglycans production. The objective of this study was to analyze the in vitro effect of different concentrations of genistein on DNA injury in mucopolysaccharidosis IVA patients. The lower concentration tested (10 μM) showed a significant increase on DNA injury in vitro, although higher concentrations (30 μM and 50 μM) showed higher DNA damage.

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Citations

Apr 14, 2015·Seminars in Cancer Biology·Stephanie C CaseyDean W Felsher
Jul 15, 2015·Cellular and Molecular Neurobiology·Marion DeonCarmen Vargas
Mar 15, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Desirèe P MarchettiCarmen R Vargas
May 6, 2015·Metabolic Brain Disease·Mateus Struecker da RosaGuilhian Leipnitz

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