In vitro effect of nitazoxanide against Entamoeba histolytica, Giardia intestinalis and Trichomonas vaginalis trophozoites

The Journal of Eukaryotic Microbiology
R Cedillo-RiveraLilian Yépez-Mulia

Abstract

Nitazoxanide, a 5-nitrothiazolyl derivative, is effective in the treatment of a broad range of parasitic infections. In vitro, it is active against several protozoa, including Cryptosporidium parvum, Blastocystis hominis, and Giardia intestinalis. The objective of this study was to determine the in vitro effect of nitazoxanide on the growth and morphology of three anaerobic protozoa (Entamoeba histolytica, Giardia intestinalis, and Trichomonas vaginalis) and to compare these effects with those of metronidazole and albendazole. A subculture method was used to determine the concentrations required to inhibit growth by 50% or 90% (IC50 and IC90,). Nitazoxanide exhibited IC50, and IC90 values of 0.017 and 0.776 microg/ml respectively, against E. histolytica, 0.004 and 0.067 microg/ml against G. intestinalis, and 0.034 and 2.04 6 microg/ml against T. vaginalis. Based on the IC90 values, nitazoxanide was more toxic than metronidazole and albendazole against E. histolytica; albendazole and nitazoxanide were more toxic than metronidazole against G. intestinalis; and metronidazole was the most toxic drug against T. vaginalis. The effects of nitazoxanide on trophozoite ultrastructure of all three parasites included cell swelling and dist...Continue Reading

References

Mar 29, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J L Finney
Jan 1, 1978·Antimicrobial Agents and Chemotherapy·J G MeingassnerM Müller
Jul 1, 1992·The Journal of protozoology·B ChavezA Martinez-Palomo
Sep 1, 1992·Journal of Medical Microbiology·R Cedillo-Rivera, O Muñoz
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·P F BorehamR W Shepherd
Oct 1, 1996·Antimicrobial Agents and Chemotherapy·L DubreuilJ F Rossignol
Oct 1, 1996·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jacqueline A UpcroftPeter Upcroft
Apr 9, 1998·The Journal of Antimicrobial Chemotherapy·P Venkatesan
May 15, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·R Romero CabelloA Geyne Cruz
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·J F RossignolH Friedman
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·C S McVay, R D Rolfe
Sep 13, 2000·International Journal of Clinical Pharmacology and Therapeutics·J BroekhuysenJ F Rossignol
Nov 4, 2000·The Journal of Antimicrobial Chemotherapy·V LeméeL Favennec
Jan 9, 2001·Clinical Microbiology Reviews·Peter Upcroft, Jacqueline A Upcroft
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P AbboudL Favennec
May 1, 1993·Parasitology Today·P J Johnson

Citations

Jul 17, 2013·Parasitology Research·Armando Pérez-RangelGloria León-Avila
Apr 5, 2005·Experimental Parasitology·Rafael Meyer MarianteMarlene Benchimol
Mar 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·LeAnne M Fox, Louis D Saravolatz
Oct 26, 2011·Antimicrobial Agents and Chemotherapy·N NagataDamien Stark
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Joachim MüllerAndrew Hemphill
May 18, 2013·BMC Complementary and Alternative Medicine·Adelina Jiménez-ArellanesLilián Yépez-Mulia
May 19, 2010·Marine Drugs·Zulema Cantillo-CiauY Freile-Pelegrin
Mar 20, 2008·Annals of Tropical Medicine and Parasitology·Angel A EscobedoR Pérez
Sep 9, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Heba AbdelKader AminouHanan Ahmed Hashem
Aug 27, 2009·Biologics : Targets & Therapy·Haendel G N O BusattiMaria A Gomes
Apr 2, 2016·Research in Veterinary Science·Félix Matadamas-MartínezLilián Yépez-Mulia
Jan 14, 2012·Veterinary Parasitology·Ruth FiechterManuela Schnyder
May 1, 2010·European Journal of Medicinal Chemistry·Francisco Hernández-LuisLilián Yépez-Mulia
Mar 17, 2009·Experimental Parasitology·Thomas GeurdenEdwin Claerebout
Aug 30, 2008·Journal of Ethnopharmacology·Rosa Moo-PucY Freile-Pelegrin
Jul 14, 2007·Journal of Ethnopharmacology·Fernando CalzadaAmparo Tapia-Contreras
Sep 8, 2015·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Hayam Mohamed Ezz Eldin, Abeer Fathy Badawy
Aug 22, 2007·Infectious Diseases in Obstetrics and Gynecology·Amy KruegerJeffrey L Jones
Aug 19, 2007·Expert Opinion on Pharmacotherapy·Angel A Escobedo, Sergio Cimerman
Apr 26, 2006·Expert Opinion on Pharmacotherapy·Andrew HemphillMarco Esposito
Dec 1, 2012·International Journal for Parasitology. Drugs and Drug Resistance·Noriyuki NagataDamien Stark
Mar 19, 2015·Parasitology Research·Hend Aly El-Taweel
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Adelina Jiménez-ArellanesLilián Yépez-Mulia
Aug 21, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E B C LimaS M M Vasconcelos
Apr 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emanuel Hernández-NúñezGabriel Navarrete Vázquez
Jan 31, 2006·Expert Review of Anti-infective Therapy·Neha NandaKaren A Wendel
Jan 31, 2017·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Aida A Abdel-MagiedAbeer A El-Henawy
Nov 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jaime Pérez-VillanuevaDante B Estrada-Castro
Mar 29, 2018·Future Medicinal Chemistry·Alfredo Meneses-MarcelVicente J Arán-Redó
May 26, 2017·Clinical Microbiology Reviews·Kawthar BouchemalPhilippe M Loiseau
Jan 10, 2019·The Cochrane Database of Systematic Reviews·Maria Liza M GonzalesJuliet Sio-Aguilar
Oct 16, 2004·Expert Review of Anti-infective Therapy·Clinton A White
Sep 17, 2003·Cell Research·Rebecca L DunneJacqueline A Upcroft
Aug 9, 2011·Journal of Biomolecular Screening·Fabian López-VallejoJosé L Medina-Franco
Jun 22, 2019·Scientific Reports·Gabriel López-VelázquezSergio Enríquez-Flores
Oct 8, 2019·International Journal of Medical Microbiology : IJMM·Julio C CarreroMireya de la Garza
Dec 29, 2020·European Journal of Medicinal Chemistry·Jaime Pérez-VillanuevaOlivia Soria-Arteche
Jun 7, 2007·Sexually Transmitted Diseases·Michael Dan, Jack D Sobel

Methods Mentioned

BETA
scanning electron microscopy

Related Concepts

Taenitaz
Metazoa
Schizonticides
Entamoeba histolytica
Entamoebiasis
Giardiasis
Bayer 5360
Scanning Electron Microscopy
Thiazoles
Trichomonas Infections

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