In vitro effectiveness of garlic (Allium sativum) extract on scolices of hydatid cyst.

World Journal of Surgery
Mohammad Moazeni, Ali Nazer

Abstract

Surgery is still the main treatment for hydatid disease. Recurrence of the infection is one of the end points of surgery in treating the hydatid cyst which results from the dissemination of protoscolices-rich fluid. Installation of a scolicidal agent into the cyst is the most commonly employed measure to prevent recurrence. Many scolicidal agents have been used for inactivation of the cyst's content, but most of them are not safe due to their undesired side effects. In the present study, the scolicidal effect of methanolic extract of Allium sativum is investigated. Protoscolices were aseptically collected from sheep livers containing hydatid cysts. Two concentrations (25 and 50 mg ml(-1)) of garlic extract were used for 10, 20, 30, 40, 50, and 60 min. Viability of protoscolices was confirmed by 0.1% eosin staining. Allium sativum extract at the concentration of 25 mg ml(-1) killed 87.9, 95.6, 96.8, 98.7, 99.6, and 100% of protoscolices following 10, 20, 30, 40, 50, and 60 min of application, respectively. Moreover, the scolicidal activity of Allium sativum extract at the concentration of 50 mg ml(-1) was 100% after 10 min of application. Methanolic extract of Allium sativum had a high scolicidal activity in vitro and thus might...Continue Reading

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Citations

Aug 16, 2011·Parasitology Research·Mohammad Moazeni, Ehsan Rakhshandehroo
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Mohammad MoazeniAmir Mootabi Alavi
Sep 9, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Mohammad Moazeni, Ali Asghar Khademolhoseini
Jul 15, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Hossein MahmoudvandMozhgan Azadpour
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Jul 30, 2014·Veterinary Parasitology·Mohammad MoazeniMohammad Jamal Saharkhiz
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Jan 17, 2012·Veterinary Parasitology·Mohammad MoazeniAli Akbar Hosseini
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Jun 16, 2017·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Mohammad MoazeniAmir Mootabi Alavi
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Jun 25, 2017·Research in Veterinary Science·Mohammad MoazeniMohammad Jamal Saharkhiz

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